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PMID: 10515835 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Borna disease virus in human brains with a rare form of hippocampal degeneration but not in brains of patients with common neuropsychiatric disorders.

The Journal of infectious diseases ·Vol. 180 ·No. 5 ·1999-11-00 ·Pages 1695-9

Czygan M, Hallensleben W, Hofer M, Pollak S, Sauder C, Bilzer T, Blümcke I, Riederer P, Bogerts B, Falkai P, Schwarz MJ, Masliah E, Staeheli P, Hufert FT, Lieb K

Abstract

To estimate the frequency of persistent Borna disease virus (BDV) infections of the human central nervous system and to determine which neuropsychiatric disorders might be associated with this viral infection, reverse transcription-nested polymerase chain reaction was used to screen a large collection of autopsy brain samples for the presence of BDV-specific nucleic acids. The presence of BDV RNA was found in 3 brains of persons with psychiatric symptoms and prominent hippocampal degeneration previously reported to be positive by others. However, no BDV RNA was detected in 86 randomly collected brains from persons with various psychiatric disorders, including schizophrenia, affective disorders, and Alzheimer's disease, or from suicide victims or in 52 brains from healthy controls. Furthermore, no BDV-RNA was detected in 16 surgical brain samples from persons with epilepsy-associated hippocampal sclerosis. These results indicate that life-long persistent BDV infections are rare in humans and that such infections may be associated with certain forms of hippocampal degeneration.

MeSH Terms

Adult Aged Aged, 80 and over Borna Disease/complications,virology Borna disease virus/genetics,isolation & purification Brain/virology Epilepsy/complications Female Hippocampus/pathology,virology Humans Male Mental Disorders/complications,virology Middle Aged Neurodegenerative Diseases/complications,virology RNA, Viral/analysis Reverse Transcriptase Polymerase Chain Reaction Sclerosis

Chemicals

RNA, Viral

Authors & Affiliations

15 authors, click to expand affiliations / ORCID

Czygan M

Abteilung Virologie, Institut für Medizinische Mikrobiologieand Hygiene, and Abteilung Psychiatrie, Universität Freiburg, Germany.

Hallensleben W

Hofer M

Pollak S

Sauder C

Bilzer T

Blümcke I

Riederer P

Bogerts B

Falkai P

Schwarz M J

Masliah E

Staeheli P

Hufert F T

Lieb K

Article Info

Journal

The Journal of infectious diseases

Abbr.

J Infect Dis

ISSN

0022-1899

DOI

10.1086/315068

Published

1999-11-00

Pages

1695-9

Language

English

Region

United States

NLM ID

0413675

Subset

Grants

NIA NIH HHS · AG-5131 · United States

Databases

GENBANK

AJ246850, AJ246851, AJ246852, AJ246853, AJ246854, AJ246855, AJ246856, AJ246857, AJ246858, AJ246859, AJ246860, AJ246861, AJ246862, AJ246863, AJ246864, AJ246865, AJ246866, AJ246867, AJ246868, AJ246869, AJ246870, AJ246871, AJ246872, AJ246873

Corrections

CommentIn

PMID: 10823802

External Links

PubMed source DOI: 10.1086/315068 View journal details

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Borna disease virus in human brains with a rare form of hippocampal degeneration but not in brains of patients with common neuropsychiatric disorders.

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