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PMID: 10508668 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Type II restriction endonucleases: structural, functional and evolutionary relationships.

Current opinion in chemical biology ·Vol. 3 ·No. 5 ·1999-10-00 ·Pages 578-83

Kovall RA, Matthews BW

Abstract

Type II restriction endonucleases are a paradigm for site-specific cleavage of DNA. Recent structural analyses, in particular in the presence of various divalent metals, have shed new insight into the mechanisms of catalysis. In addition, during this past year the crystal structure determinations of MutH, lambda-exonuclease and FokI have revealed that these proteins are also members of the same family.

MeSH Terms

Animals Deoxyribonucleases, Type II Site-Specific/chemistry,physiology Evolution, Molecular Humans Models, Molecular Protein Conformation Structure-Activity Relationship

Chemicals

Deoxyribonucleases, Type II Site-Specific

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kovall R A

Institute of Molecular Biology, Howard Hughes Medical Institute, Department of Physics, 1229 University of Oregon, Eugene, OR 97403-1229, USA.

Matthews B W

Article Info

Journal

Current opinion in chemical biology

Abbr.

Curr Opin Chem Biol

ISSN

1367-5931

DOI

10.1016/s1367-5931(99)00012-5

Published

1999-10-00

Pages

578-83

Language

English

Region

England

NLM ID

9811312

Subset

Grants

NIGMS NIH HHS · GM20066 · United States

External Links

PubMed source DOI: 10.1016/s1367-5931(99)00012-5 View journal details

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Type II restriction endonucleases: structural, functional and evolutionary relationships.

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