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PMID: 10508651 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Proteolysis and cell migration: creating a path?

Current opinion in cell biology ·Vol. 11 ·No. 5 ·1999-10-00 ·Pages 614-21

Murphy G, Gavrilovic J

Abstract

Both serine and metalloproteinases have been implicated in the complex integrated events underlying cell migration but no definitive single mechanism has emerged. Work over the past two years linking both membrane and soluble proteinases with integrins and other adhesion proteins and with intracellular signalling systems could herald the beginnings of a potential expansion of our understanding of the role and regulation of proteolysis in cell migration.

MeSH Terms
Animals Cell Movement/physiology Endopeptidases/physiology Endothelium, Vascular/enzymology,injuries Extracellular Matrix/metabolism Extracellular Matrix Proteins/physiology Fibrinolysin/physiology Humans Keratinocytes/cytology Metalloendopeptidases/physiology Mice Mice, Knockout Neoplasm Invasiveness Neoplasm Proteins/physiology Osteoclasts/cytology Proteins/metabolism Receptors, Cell Surface/physiology Receptors, Urokinase Plasminogen Activator Serine Endopeptidases/physiology Urokinase-Type Plasminogen Activator/physiology
Chemicals
Extracellular Matrix Proteins Neoplasm Proteins PLAUR protein, human Plaur protein, mouse Proteins Receptors, Cell Surface Receptors, Urokinase Plasminogen Activator Endopeptidases Serine Endopeptidases Fibrinolysin Urokinase-Type Plasminogen Activator Metalloendopeptidases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Murphy G
School of Biological Sciences University of East Anglia Norwich, NR4 7TJ, UK. g.murphy@uea.ac.uk.
Gavrilovic J
Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
0955-0674
DOI
10.1016/s0955-0674(99)00022-8
Email
g.murphy@uea.ac.uk
Published
1999-10-00
Pages
614-21
Language
English
Region
England
NLM ID
8913428
Subset
IM
Grants
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1016/s0955-0674(99)00022-8 View journal details
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