Fibronectin fibrillogenesis: a paradigm for extracellular matrix assembly.

Current opinion in cell biology ·Vol. 11 ·No. 5 ·1999-10-00 ·Pages 622-7

Schwarzbauer JE, Sechler JL

Abstract

Fibronectin matrix assembly is a regulated stepwise process. In the past year, analyses of fibronectin domains, integrin and cytoskeletal contributions, and fibril architecture have provided new insights into assembly mechanisms and matrix control of cell functions. Like fibronectin, laminin polymerization is cell-mediated. Thus a common pathway for extracellular matrix assembly is emerging.

MeSH Terms

Animals Basement Membrane/metabolism,ultrastructure CHO Cells Cell Differentiation Cell Movement Cells, Cultured Cricetinae Cricetulus Extracellular Matrix/metabolism,ultrastructure Fibronectins/chemistry,metabolism Integrins/metabolism Laminin/metabolism Microfibrils/metabolism Motion Protein Binding Protein Conformation Protein Structure, Tertiary

Chemicals

Fibronectins Integrins Laminin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Schwarzbauer J E

Department of Molecular Biology Princeton University Princeton, NJ 08544-1014, USA. jschwarzbauer@molbio.princeton.edu.

Sechler J L

Article Info

Journal

Current opinion in cell biology

Abbr.

Curr Opin Cell Biol

ISSN

0955-0674

DOI

10.1016/s0955-0674(99)00017-4

jschwarzbauer@molbio.princeton.edu

Published

1999-10-00

Pages

622-7

Language

English

Region

England

NLM ID

8913428

Subset

External Links

PubMed source DOI: 10.1016/s0955-0674(99)00017-4 View journal details

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