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PMID: 10508511 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Fv2 encodes a truncated form of the Stk receptor tyrosine kinase.

Nature genetics ·Vol. 23 ·No. 2 ·1999-10-00 ·Pages 159-65

Persons DA, Paulson RF, Loyd MR, Herley MT, Bodner SM, Bernstein A, Correll PH, Ney PA

Abstract

The Friend virus susceptibility 2 (Fv2) locus encodes a dominant host factor that confers susceptibility to Friend virus-induced erythroleukaemia in mice. We mapped Fv2 to a 1.0-Mb interval that also contained the gene (Ron) encoding the stem cell kinase receptor (Stk). A truncated form of Stk (Sf-stk), which was the most abundant form of Stk in Fv2-sensitive (Fv2ss) erythroid cells, was not expressed in Fv2 resistant (Fv2rr) cells. Enforced expression of Sf-stk conferred susceptibility to Friend disease, whereas targeted disruption of Ron caused resistance. We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia.

MeSH Terms

3T3 Cells Animals Base Sequence Chromosome Mapping Cloning, Molecular Contig Mapping Friend murine leukemia virus Gene Expression Genetic Predisposition to Disease Leukemia, Erythroblastic, Acute/genetics Mice Mice, Inbred AKR Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred CBA Mice, Inbred NZB Mice, Inbred Strains Molecular Sequence Data Muridae Protein Isoforms/genetics Receptor Protein-Tyrosine Kinases/genetics Receptors, Cell Surface/genetics Retroviridae Infections/genetics Species Specificity Spleen/cytology,metabolism,pathology Tumor Virus Infections/genetics

Chemicals

Protein Isoforms Receptors, Cell Surface RON protein Receptor Protein-Tyrosine Kinases

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Persons D A

Department of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

Paulson R F

Loyd M R

Herley M T

Bodner S M

Bernstein A

Correll P H

Ney P A

Article Info

Journal

Nature genetics

Abbr.

Nat Genet

ISSN

1061-4036

DOI

10.1038/13787

Published

1999-10-00

Pages

159-65

Language

English

Region

United States

NLM ID

9216904

Subset

Grants

NCI NIH HHS · R01 CA084214-02 · United States

NCI NIH HHS · R01 CA084214-03 · United States

NCI NIH HHS · R01 CA084214-05 · United States

NCI NIH HHS · P30 CA21765 · United States

NCI NIH HHS · R01 CA084214-04 · United States

NCI NIH HHS · R01 CA084214 · United States

NCI NIH HHS · R01 CA084214-01 · United States

Corrections

CommentIn

PMID: 10508499

External Links

PubMed source DOI: 10.1038/13787 View journal details

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Fv2 encodes a truncated form of the Stk receptor tyrosine kinase.

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