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PMID: 10496341 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Microsatellite instability in sporadic colorectal cancer is not an independent prognostic factor.

British journal of cancer ·Vol. 81 ·No. 2 ·1999-09-00 ·Pages 190-3

Salahshor S, Kressner U, Fischer H, Lindmark G, Glimelius B, Påhlman L, Lindblom A

Abstract

Hereditary non-polyposis colorectal cancer (HNPCC) is linked to an inherited defect in the DNA mismatch repair system. DNA from HNPCC tumours shows microsatellite instability (MSI). It has been reported that HNPCC patients have a better prognosis than patients with sporadic colorectal cancer. We examined whether the presence of MSI in a series of unselected colorectal tumours carries prognostic information. In a series of 181 unselected colorectal tumours, 22 tumours (12%) showed MSI. Survival analysis at 5-10 years follow-up showed no statistically significant difference in prognosis between MSI-positive and -negative tumours. Our results suggest that the MSI phenotype as such is not an independent prognostic factor.

MeSH Terms
Aged Colorectal Neoplasms/genetics,mortality DNA, Neoplasm/analysis Female Humans Male Microsatellite Repeats Middle Aged Prognosis Survival Analysis
Chemicals
DNA, Neoplasm
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Salahshor S
Department of Molecular Medicine, Karolinska Institute, Stockholm, Sweden.
Kressner U
Fischer H
Lindmark G
Glimelius B
Påhlman L
Lindblom A
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/sj.bjc.6690676
Published
1999-09-00
Pages
190-3
Language
English
Region
England
NLM ID
0370635
PMCID
PMC2362857
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.bjc.6690676 PMC Full Text View journal details
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