Characterization and expression of sema4g, a novel member of the semaphorin gene family.

Mechanisms of development ·Vol. 87 ·No. 1-2 ·1999-09-00 ·Pages 169-73

Li H, Wu DK, Sullivan SL

Abstract

Semaphorins constitute a large and growing gene family, several members of which are axon guidance molecules. We report the characterization of sema4g, a novel class IV member of the semaphorin gene family, located on mouse chromosome 19. sema4g is expressed early in development in the brain, spinal cord, and several sensory organs as well as specific populations of projection neurons, compatible with the well-established function of semaphorins as axon guidance molecules.

MeSH Terms

Amino Acid Sequence Animals Axons/metabolism,physiology Brain/metabolism Chromosome Mapping Chromosomes, Human, Pair 10 DNA, Complementary/metabolism Gene Expression Regulation, Developmental Gene Library Humans In Situ Hybridization Kidney/metabolism Liver/metabolism Membrane Proteins/genetics,metabolism Mice Molecular Sequence Data Nerve Growth Factors/genetics,metabolism Nerve Tissue Proteins/metabolism Nervous System/embryology,metabolism Physical Chromosome Mapping Semaphorins Sequence Homology, Amino Acid Tissue Distribution

Chemicals

DNA, Complementary Membrane Proteins Nerve Growth Factors Nerve Tissue Proteins Sema4g protein, mouse Semaphorins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Li H

Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA.

Wu D K

Sullivan S L

Article Info

Journal

Mechanisms of development

Abbr.

Mech Dev

ISSN

0925-4773

DOI

10.1016/s0925-4773(99)00125-2

Published

1999-09-00

Pages

169-73

Language

English

Region

Ireland

NLM ID

9101218

Subset

Databases

GENBANK

AF134918

External Links

PubMed source DOI: 10.1016/s0925-4773(99)00125-2 View journal details

Analysis Services

Characterization and expression of sema4g, a novel member of the semaphorin gene family.

Contact

WeChat Official Account