Mitochondria in the life and death of neurons.

Essays in biochemistry ·Vol. 33 ·1998-00-00 ·Pages 43-52

Budd SL, Nicholls DG

Abstract

A prolonged decrease in ATP levels underlies a number of neurodegenerative disorders. Defects in oxidative phosphorylation are associated with a number of neurodegenerative disorders. Mitochondria also play an important role in mediating the initiation of apoptosis.

MeSH Terms

Alzheimer Disease/etiology Animals Apoptosis/physiology Energy Metabolism Humans Mitochondria/metabolism Mitochondrial Myopathies/etiology Models, Neurological Neurodegenerative Diseases/etiology Neurons/cytology,metabolism Parkinson Disease/etiology Receptors, N-Methyl-D-Aspartate/metabolism

Chemicals

Receptors, N-Methyl-D-Aspartate

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Budd S L

CNS Research Institute, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Nicholls D G

Article Info

Journal

Essays in biochemistry

Abbr.

Essays Biochem

ISSN

0071-1365

DOI

10.1042/bse0330043

Published

1998-00-00

Pages

43-52

Language

English

Region

England

NLM ID

0043306

Subset

External Links

PubMed source DOI: 10.1042/bse0330043 View journal details

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Mitochondria in the life and death of neurons.

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