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PMID: 10488206 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Molecular characterization of a Shiga toxigenic Escherichia coli O113:H21 strain lacking eae responsible for a cluster of cases of hemolytic-uremic syndrome.

Journal of clinical microbiology ·Vol. 37 ·No. 10 ·1999-10-00 ·Pages 3357-61

Paton AW, Woodrow MC, Doyle RM, Lanser JA, Paton JC

Abstract

Shiga toxigenic Escherichia coli (STEC) strains are a diverse group of organisms capable of causing severe gastrointestinal disease in humans. Within the STEC family, certain strains appear to have greater virulence for humans. STEC strains carrying eae and belonging to serogroup O157 or O111 have been responsible for the vast majority of outbreaks of STEC disease reported to date. Here we describe a STEC O113:H21 strain lacking eae that was responsible for a cluster of three cases of hemolytic-uremic syndrome. This strain produces a single Stx2-related toxin and adheres efficiently to Henle 407 cells.

MeSH Terms
Adhesins, Bacterial Amino Acid Sequence Antibodies, Bacterial/blood Bacterial Adhesion Bacterial Outer Membrane Proteins/genetics Bacterial Toxins/genetics Carrier Proteins Child Escherichia coli/genetics,immunology,pathogenicity Escherichia coli Proteins Hemolytic-Uremic Syndrome/microbiology Humans Molecular Sequence Data Polymerase Chain Reaction Shiga Toxins
Chemicals
Adhesins, Bacterial Antibodies, Bacterial Bacterial Outer Membrane Proteins Bacterial Toxins Carrier Proteins Escherichia coli Proteins Shiga Toxins eaeA protein, E coli
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Paton A W
Molecular Microbiology Unit, Women's and Children's Hospital, North Adelaide, S.A. 5006, Australia.
Woodrow M C
Doyle R M
Lanser J A
Paton J C
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Article Info
Journal
Journal of clinical microbiology
Abbr.
J Clin Microbiol
ISSN
0095-1137
DOI
10.1128/JCM.37.10.3357-3361.1999
Published
1999-10-00
Pages
3357-61
Language
English
Region
United States
NLM ID
7505564
PMCID
PMC85566
Subset
IM
External Links
PubMed source DOI: 10.1128/JCM.37.10.3357-3361.1999 PMC Full Text View journal details
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