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PMID: 10471714 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Population structure among African and derived populations of Drosophila simulans: evidence for ancient subdivision and recent admixture.

Genetics ·Vol. 153 ·No. 1 ·1999-09-00 ·Pages 305-17

Hamblin MT, Veuille M

Abstract

Previous studies based on allozyme variation have found little evidence for genetic differentiation in Drosophila simulans. On the basis of DNA sequence variation at two nuclear loci in four African populations of D. simulans, we show that there is significant structure to D. simulans populations within Africa. Variation at one of the loci, vermilion, appears to be neutral and supports an eastern African origin for European and American populations. Samples from the West Indies, Europe, and North America had a nucleotide diversity lower than that of African populations at vermilion and show nonequilibrium haplotype distributions at both vermilion and G6pd, consistent with a hypothesis of recent bottleneck and possibly also admixture in the history of these populations. Directional selection, previously documented at G6pd, appears to have occurred within the coalescence time of the species, obscuring deep population history.

MeSH Terms
Africa Animals Base Sequence Drosophila/enzymology,genetics Drosophila Proteins Europe Eye Proteins Gene Frequency Genes, Insect/genetics Genetic Variation/genetics Glucosephosphate Dehydrogenase/genetics Haplotypes/genetics Insect Proteins/genetics Male Models, Genetic Molecular Sequence Data North America Phylogeny Polymorphism, Genetic/genetics Recombination, Genetic Sequence Analysis, DNA Sex Chromosomes/genetics Tryptophan Oxygenase West Indies
Chemicals
Drosophila Proteins Eye Proteins Insect Proteins Glucosephosphate Dehydrogenase Tryptophan Oxygenase v protein, Drosophila
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hamblin M T
Laboratoire d'Ecologie-EPHE, Université Pierre-et-Marie Curie, 75252 Paris Cedex 05, France. mhamblin@genetics.uchicago.edu
Veuille M
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/153.1.305
Email
mhamblin@genetics.uchicago.edu
Published
1999-09-00
Pages
305-17
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1460727
Subset
IM
Databases
GENBANK
AF148146, AF148147, AF148148, AF148149, AF148150, AF148151, AF148152, AF148153, AF148154, AF148155, AF148156, AF148157, AF148158, AF148159, AF148160, AF148161, AF148162, AF148163, AF148164, AF148165, AF148166, AF148167, AF148168, AF148169, AF148170, AF148171, AF148172, AF148173, AF148174, AF148175
External Links
PubMed source DOI: 10.1093/genetics/153.1.305 PMC Full Text View journal details
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