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PMID: 10465176 Published · ppublish English Letter Research Support, Non-U.S. Gov't

Altered lung antioxidant status in patients with mild asthma.

Lancet (London, England) ·Vol. 354 ·No. 9177 ·1999-08-07 ·Pages 482-3

Kelly FJ, Mudway I, Blomberg A, Frew A, Sandström T

Abstract

Lung lining fluid ascorbic acid (vitamin C) and alpha-tocopherol (vitamin E) concentrations are low in patients with mild asthma even though blood levels are normal or increased. These findings, along with the presence of increased amounts of oxidised glutathione in their airways, indicate that patients with asthma are subject to increased oxidative stress.

MeSH Terms

Antioxidants/metabolism Ascorbic Acid/metabolism Asthma/diagnosis,metabolism Bronchoalveolar Lavage Fluid/chemistry Chromatography, High Pressure Liquid Glutathione/metabolism Humans Lung/metabolism Oxidation-Reduction Reference Values Vitamin E/metabolism

Chemicals

Antioxidants Vitamin E Glutathione Ascorbic Acid

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Kelly F J

Mudway I

Blomberg A

Frew A

Sandström T

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/S0140-6736(99)01812-7

Published

1999-08-07

Pages

482-3

Language

English

Region

England

NLM ID

2985213R

Subset

Grants

Wellcome Trust · United Kingdom

External Links

PubMed source DOI: 10.1016/S0140-6736(99)01812-7 View journal details

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Altered lung antioxidant status in patients with mild asthma.

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