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PMID: 10455495 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Genetic engineering of doxorubicin production in Streptomyces peucetius: a review.

Journal of industrial microbiology & biotechnology ·Vol. 23 ·No. 1 ·1999-07-00 ·Pages 647-52

Hutchinson CR, Colombo AL

Abstract

The genetics and biochemistry of daunorubicin and doxorubicin production by Streptomyces peucetius is reviewed, with a focus on how such information can be used for the genetic engineering of strains having improved titers of these two antitumor antibiotics.

MeSH Terms
Antineoplastic Agents/metabolism Daunorubicin/biosynthesis,metabolism Doxorubicin/biosynthesis Genetic Engineering/methods Humans Streptomyces/metabolism
Chemicals
Antineoplastic Agents Doxorubicin Daunorubicin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hutchinson C R
School of Pharmacy and Department of Bacteriology, University of Wisconsin, Madison 53706, USA.
Colombo A L
Article Info
Journal
Journal of industrial microbiology & biotechnology
Abbr.
J Ind Microbiol Biotechnol
ISSN
1367-5435
DOI
10.1038/sj.jim.2900673
Published
1999-07-00
Pages
647-52
Language
English
Region
Germany
NLM ID
9705544
Subset
IM
Grants
NCI NIH HHS · CA64161 · United States
External Links
PubMed source DOI: 10.1038/sj.jim.2900673 View journal details
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