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PMID: 10454356 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Alpha7 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice.

Learning & memory (Cold Spring Harbor, N.Y.) ·Vol. 5 ·No. 4-5 ·1998-00-00 ·Pages 302-16

Paylor R, Nguyen M, Crawley JN, Patrick J, Beaudet A, Orr-Urtreger A

Abstract

The alpha7 nicotinic acetylcholine receptor (nAChR) subunit is abundantly expressed in the hippocampus and contributes to hippocampal cholinergic synaptic transmission suggesting that it may contribute to learning and memory. There is also evidence for an association between levels of alpha7 nAChR and in sensorimotor gating impairments. To examine the role of alpha7 nAChRs in learning and memory and sensorimotor gating, Acra7 homozygous mutant mice and their wild-type littermates were tested in a Pavlovian conditioned fear test, for spatial learning in the Morris water task, and in the prepulse inhibition paradigm. Exploratory activity, motor coordination, and startle habituation were also evaluated. Acra7 mutant mice displayed the same levels of contextual and auditory-cue condition fear as wild-type mice. Similarly, there were no differences in spatial learning performance between mutant and wild-type mice. Finally, Acra7 mutant and wild-type mice displayed similar levels of prepulse inhibition. Other behavioral responses in Acra7 mutant mice were also normal, except for an anxiety-related behavior in the open-field test. The results of this study show that the absence of alpha7 nAChRs has little impact on normal, base-line behavioral responses. Future studies will examine the contribution of alpha7 nAChR to the enhancement of learning and sensorimotor gating following nicotine treatments.

MeSH Terms
Animals Conditioning, Classical Darkness Exploratory Behavior/physiology Fear Hippocampus/physiology Homozygote Learning/physiology Light Mice Mice, Knockout Motor Activity/physiology Pain Psychomotor Performance Receptors, Nicotinic/deficiency,genetics,physiology Reflex, Startle Synaptic Transmission alpha7 Nicotinic Acetylcholine Receptor
Chemicals
Chrna7 protein, mouse Receptors, Nicotinic alpha7 Nicotinic Acetylcholine Receptor
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Paylor R
Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Bethesda, Maryland 20892, USA.
Nguyen M
Crawley J N
Patrick J
Beaudet A
Orr-Urtreger A
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Article Info
Journal
Learning & memory (Cold Spring Harbor, N.Y.)
Abbr.
Learn Mem
ISSN
1072-0502
Published
1998-00-00
Pages
302-16
Language
English
Region
United States
NLM ID
9435678
PMCID
PMC311270
Subset
IM
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