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PMID: 10452616 Published · ppublish English Journal Article

p53 Family members p63 and p73 are SAM domain-containing proteins.

Protein science : a publication of the Protein Society ·Vol. 8 ·No. 8 ·1999-08-00 ·Pages 1708-10

Thanos CD, Bowie JU

Abstract

Homologs of the tumor suppressor p53, called p63 and p73, have been identified. The p63 and p73 family members possess a domain structure similar to p53, but contain variable C-terminal extensions. We find that some of the C-terminal extensions contain Sterile Alpha Motif (SAM) domains. SAM domains are protein modules that are involved in protein-protein interactions. Consistent with this role, the C-terminal SAM domains of the p63 and p73 may regulate function by recruiting other protein effectors.

MeSH Terms
Amino Acid Sequence Animals DNA-Binding Proteins/genetics Genes, Tumor Suppressor Humans Membrane Proteins Molecular Sequence Data Nuclear Proteins/genetics Phosphoproteins/chemistry Sequence Homology, Amino Acid Trans-Activators Transcription Factors Tumor Protein p73 Tumor Suppressor Protein p53/chemistry Tumor Suppressor Proteins
Chemicals
CKAP4 protein, human DNA-Binding Proteins Membrane Proteins Nuclear Proteins Phosphoproteins TP63 protein, human TP73 protein, human Trans-Activators Transcription Factors Tumor Protein p73 Tumor Suppressor Protein p53 Tumor Suppressor Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Thanos C D
Department of Chemistry and Biochemistry, University of California-Los Angeles, 90095, USA.
Bowie J U
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Article Info
Journal
Protein science : a publication of the Protein Society
Abbr.
Protein Sci
ISSN
0961-8368
DOI
10.1110/ps.8.8.1708
Published
1999-08-00
Pages
1708-10
Language
English
Region
United States
NLM ID
9211750
PMCID
PMC2144426
Subset
IM
External Links
PubMed source DOI: 10.1110/ps.8.8.1708 PMC Full Text View journal details
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