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PMID: 10450970 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Lobophorins A and B, new antiinflammatory macrolides produced by a tropical marine bacterium.

Bioorganic & medicinal chemistry letters ·Vol. 9 ·No. 14 ·1999-07-19 ·Pages 2003-6

Jiang ZD, Jensen PR, Fenical W

Abstract

Two new antiinflammatory macrolides, lobophorins A and B (1 and 2), have been isolated from fermentation broths of a marine bacterium isolated from the surface the Caribbean brown alga Lobophora variegata (Dictyotales). The new compounds, distantly related to antibiotics of the kijanimicin class, are potent inhibitors of topical PMA-induced edema in the mouse ear assay when administered either topically or IP.

MeSH Terms
Actinomycetales/chemistry,metabolism Administration, Topical Animals Anti-Inflammatory Agents/isolation & purification,metabolism,pharmacology Ear Diseases/chemically induced,drug therapy Edema/chemically induced,drug therapy Fermentation Injections, Intraperitoneal Macrolides/chemistry,isolation & purification,metabolism,pharmacology Magnetic Resonance Spectroscopy Mice Molecular Structure Tetradecanoylphorbol Acetate/toxicity Water Microbiology
Chemicals
Anti-Inflammatory Agents Macrolides lobophorin A lobophorin B Tetradecanoylphorbol Acetate
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Jiang Z D
Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0236, USA.
Jensen P R
Fenical W
Article Info
Journal
Bioorganic & medicinal chemistry letters
Abbr.
Bioorg Med Chem Lett
ISSN
0960-894X
DOI
10.1016/s0960-894x(99)00337-6
Published
1999-07-19
Pages
2003-6
Language
English
Region
England
NLM ID
9107377
Subset
IM
Grants
NCI NIH HHS · CA44848 · United States
External Links
PubMed source DOI: 10.1016/s0960-894x(99)00337-6 View journal details
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