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PMID: 10440237 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Regulation of the iron regulatory proteins by reactive nitrogen and oxygen species.

Gene expression ·Vol. 7 ·No. 4-6 ·1999-00-00 ·Pages 367-76

Hanson ES, Leibold EA

Abstract

Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are RNA binding proteins that posttranscriptionally regulate the expression of mRNAs coding for proteins involved in the maintenance of iron and energy homeostasis. The RNA binding activities of the IRPs are regulated by changes in cellular iron. Thus, the IRPs are considered iron sensors and the principle regulators of cellular iron homeostasis. The mechanisms governing iron regulation of the IRPs are well described. Recently, however, much attention has focused on the regulation of IRPs by reactive nitrogen and oxygen species (RNS, ROS). Here we focus on summarizing the iron-regulated RNA binding activities of the IRPs, as well as the recent findings of IRP regulation by RNS and ROS. The recent observations that changes in oxygen tension regulate both IRP1 and IRP2 RNA binding activities will be addressed in light of ROS regulation of the IRPs.

MeSH Terms
Animals Homeostasis Iron/metabolism Iron Regulatory Protein 1 Iron Regulatory Protein 2 Iron-Regulatory Proteins Iron-Sulfur Proteins/metabolism Nitric Oxide/metabolism Nitrogen/metabolism RNA-Binding Proteins/metabolism Reactive Oxygen Species/metabolism
Chemicals
Iron-Regulatory Proteins Iron-Sulfur Proteins RNA-Binding Proteins Reactive Oxygen Species Nitric Oxide Iron Iron Regulatory Protein 1 Iron Regulatory Protein 2 Nitrogen
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hanson E S
Department of Medicine, University of Utah, Salt Lake City 84112, USA.
Leibold E A
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Article Info
Journal
Gene expression
Abbr.
Gene Expr
ISSN
1052-2166
Published
1999-00-00
Pages
367-76
Language
English
Region
United States
NLM ID
9200651
PMCID
PMC6174660
Subset
IM
Grants
NIGMS NIH HHS · R01 GM045201 · United States
NIDDK NIH HHS · T32 DK007115 · United States
NIGMS NIH HHS · GM45201 · United States
NIDDK NIH HHS · T32 DK07115 · United States
External Links
PubMed source PMC Full Text View journal details
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