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PMID: 10433957 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Estrogen receptor expression in prostate cancer and premalignant prostatic lesions.

The American journal of pathology ·Vol. 155 ·No. 2 ·1999-08-00 ·Pages 641-7

Bonkhoff H, Fixemer T, Hunsicker I, Remberger K

Abstract

Estrogens have been implicated in prostatic cancerogenesis and tumor progression. The mechanisms underlying estrogen signaling in human prostate tissue, however, remain poorly understood. Using immunohistochemical and in situ hybridization (ISH) techniques, the present study demonstrates the classical estrogen receptor (ERalpha) in premalignant lesions and prostatic adenocarcinoma through the various stages of the disease. Conversely, the novel characterized ERbeta subtype was undetectable in human prostate tissue. High-grade prostatic intraepithelial neoplasia revealed ERalpha mRNA and protein expression in 28% and 11% of cases evaluated. Focal ER immunoreactivity was detected in a minority of low- to intermediate-grade adenocarcinoma. High-grade (primary Gleason grade 4 and 5) tumors revealed ER protein expression in 43% (62% respectively) of cases. The most significant ERalpha gene expression on mRNA and protein levels was observed in hormone refractory tumors and metastatic lesions, including lymph node and bone metastases. Results of the current study suggest that estrogens can affect prostatic cancerogenesis and neoplastic progression through an ER-mediated process in human prostate tissue.

MeSH Terms
Adenocarcinoma/metabolism Endothelium/anatomy & histology,metabolism Female Hormones/therapeutic use Humans Immunohistochemistry In Situ Hybridization Lymph Nodes/metabolism Male Ovary/metabolism Precancerous Conditions/metabolism Prostatic Diseases/metabolism,pathology Prostatic Neoplasms/drug therapy,metabolism,pathology Receptors, Estrogen/metabolism Uterine Cervical Neoplasms/metabolism,pathology
Chemicals
Hormones Receptors, Estrogen
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bonkhoff H
Institute of Pathology, University of the Saarland, Homburg/Saar, Germany.
Fixemer T
Hunsicker I
Remberger K
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
DOI
10.1016/S0002-9440(10)65160-7
Published
1999-08-00
Pages
641-7
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC1866870
Subset
IM
External Links
PubMed source DOI: 10.1016/S0002-9440(10)65160-7 PMC Full Text View journal details
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