Unusual resistance to ionizing radiation of the viruses of kuru, Creutzfeldt-Jakob disease, and scrapie.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 75 ·No. 12 ·1978-12-00 ·Pages 6268-70

Gibbs CJ, Gajdusek DC, Latarjet R

Abstract

The titers of several preparations of kuru. Creutzfeldt-Jacob disease, and scrapie viruses were reduced by only 1/10th or less by high doses of gamma radiation of 50 kGy and by only 1/10th-1/1000th or less for 200 kGy. This unusual radiation resistance of the two human viruses further links them with the scrapie virus and suggests that the genetic information of all three viruses is considerably smaller than that of any other known viruses of mammals.

MeSH Terms

Creutzfeldt-Jakob Syndrome/microbiology Dose-Response Relationship, Radiation Gamma Rays Humans Kuru/microbiology Molecular Weight Prions/radiation effects,ultrastructure Viruses, Unclassified/radiation effects

Chemicals

Prions

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Gibbs C J

Gajdusek D C

Latarjet R

References (7)

7 references, click to expand

A new and rapid method for isolating viruses by selective fluorocarbon deproteinization.
Trans N Y Acad Sci. 1956 Jun;18(8):701-3 PMID: 13352364
Unconventional viruses and the origin and disappearance of kuru.
Science. 1977 Sep 2;197(4307):943-60 PMID: 142303
Potato spindle tuber viroid. XI. A comparison of the ultraviolet light sensitivities of PSTV, tobacco ringspot virus, and its satellite.
Virology. 1974 Feb;57(2):577-81 PMID: 4817076
Partial purification of the scrapie agent from mouse brain by pressure disruption and zonal centrifugation in sucrose-sodium chloride gradients.
Virology. 1976 Mar;70(1):230-7 PMID: 816078
Does the agent of scrapie replicate without nucleic acid?
Nature. 1967 May 20;214(5090):764-6 PMID: 4963878
Inactivation of the scrapie agent by near monochromatic ultraviolet light.
Nature. 1970 Sep 26;227(5265):1341-3 PMID: 4989433
The exceptionally small size of the scrapie agent.
Biochem Biophys Res Commun. 1966 Feb 3;22(3):278-84 PMID: 4957205

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.75.12.6268

Published

1978-12-00

Pages

6268-70

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC393162

Subset

External Links

PubMed source DOI: 10.1073/pnas.75.12.6268 PMC Full Text View journal details

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Unusual resistance to ionizing radiation of the viruses of kuru, Creutzfeldt-Jakob disease, and scrapie.

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