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PMID: 10426317 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Rapid selection of complement-inhibiting protein variants in group A Streptococcus epidemic waves.

Nature medicine ·Vol. 5 ·No. 8 ·1999-08-00 ·Pages 924-9

Hoe NP, Nakashima K, Lukomski S, Grigsby D, Liu M, Kordari P, Dou SJ, Pan X, Vuopio-Varkila J, Salmelinna S, McGeer A, Low DE, Schwartz B, Schuchat A, Naidich S, De Lorenzo D, Fu YX, Musser JM

Abstract

Serotype M1 group A Streptococcus strains cause epidemic waves of human infections long thought to be mono- or pauciclonal. The gene encoding an extracellular group A Streptococcus protein (streptococcal inhibitor of complement) that inhibits human complement was sequenced in 1,132 M1 strains recovered from population-based surveillance of infections in Canada, Finland and the United States. Epidemic waves are composed of strains expressing a remarkably heterogeneous array of variants of streptococcal inhibitor of complement that arise very rapidly by natural selection on mucosal surfaces. Thus, our results enhance the understanding of pathogen population dynamics in epidemic waves and infectious disease reemergence.

MeSH Terms
Animals Antigenic Variation/genetics Antigens, Bacterial Bacterial Outer Membrane Proteins Bacterial Proteins/genetics Canada Carrier Proteins/genetics Chromosomes, Bacterial/genetics Complement Hemolytic Activity Assay Complement Inactivator Proteins/genetics Disease Outbreaks Finland Mice Mucous Membrane/microbiology Pharyngitis/microbiology Phylogeny Streptococcal Infections/epidemiology Streptococcus pyogenes/genetics,immunology,isolation & purification United States
Chemicals
Antigens, Bacterial Bacterial Outer Membrane Proteins Bacterial Proteins Carrier Proteins Complement Inactivator Proteins SIC protein, Streptococcus streptococcal M protein
Authors & Affiliations
18 authors, click to expand affiliations / ORCID
Hoe N P
Institute for the Study of Human Bacterial Pathogenesis, Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA.
Nakashima K
Lukomski S
Grigsby D
Liu M
Kordari P
Dou S J
Pan X
Vuopio-Varkila J
Salmelinna S
McGeer A
Low D E
Schwartz B
Schuchat A
Naidich S
De Lorenzo D
Fu Y X
Musser J M
Article Info
Journal
Nature medicine
Abbr.
Nat Med
ISSN
1078-8956
DOI
10.1038/11369
Published
1999-08-00
Pages
924-9
Language
English
Region
United States
NLM ID
9502015
Subset
IM
Grants
NIAID NIH HHS · AI-33119 · United States
NIGMS NIH HHS · GM-50428 · United States
Databases
GENBANK
AF232306, AF232307, AF232308, AF232309, AF232310, AF232311, AF232312, AF232313, AF232314, AF232315, AF232316, AF232317, AF232318, AF232319, AF232320, AF232321, AF232322, AF232323, AF232324, AF232325, AF232326, AF232327, AF232328, AF232329, AF232330, AF232331, AF232332, AF232333, AF232334, AF232335
External Links
PubMed source DOI: 10.1038/11369 View journal details
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