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题目:: DNA mismatch repair deficiency in curatively resected sextuple primary cancers in different organs: a molecular case report.
作者:: Yakushiji(H),Mukai(S),Matsukura(S),Sato(S),Ogawa(A),Sasatomi(E),Miyazaki(K)
状态:: 发布时间1999-08-16 , 更新时间 2006-11-15
期刊:: Cancer Lett
摘要:: A male patient synchronously or metachronously underwent six curative resections after diagnoses of cancers in the rectum, urinary bladder, stomach, colon, liver and lung. Five cancers, excluding early colon cancer, were analyzed for instability in seven microsatellite markers and in transforming growth factor beta type II receptor, insulin-like growth factor II receptor and BAX. All analyzed cancers had replication errors and instability in at least one target gene. These results suggest that abnormal DNA mismatch repair system plays a major role in the occurrence of multiple primary cancers in this case.
语言:: eng
DOI:

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