Chromatin remodeling and leukemia: new therapeutic paradigms.

Acetylation Antineoplastic Agents/therapeutic use Cell Differentiation/drug effects Chromatin/metabolism,ultrastructure Chromosomal Proteins, Non-Histone/physiology Core Binding Factor Alpha 2 Subunit DNA-Binding Proteins/genetics,physiology Enzyme Inhibitors/therapeutic use Gene Expression Regulation, Leukemic Histone Deacetylase Inhibitors Histone-Lysine N-Methyltransferase Histones/chemistry,physiology Humans Leukemia/genetics,metabolism Leukemia, Promyelocytic, Acute/drug therapy,genetics,metabolism Models, Genetic Myeloid-Lymphoid Leukemia Protein Neoplasm Proteins/physiology Nucleic Acid Conformation Nucleosomes/ultrastructure Oncogene Proteins, Fusion/physiology Protein Processing, Post-Translational Proto-Oncogenes RUNX1 Translocation Partner 1 Protein Recombinant Fusion Proteins/physiology Static Electricity Transcription Factors/physiology Translocation, Genetic Tretinoin/pharmacology,therapeutic use

AML1-ETO fusion protein, human Antineoplastic Agents Chromatin Chromosomal Proteins, Non-Histone Core Binding Factor Alpha 2 Subunit DNA-Binding Proteins Enzyme Inhibitors Histone Deacetylase Inhibitors Histones KMT2A protein, human Neoplasm Proteins Nucleosomes Oncogene Proteins, Fusion PLZF-RARalpha fusion protein, human RUNX1 Translocation Partner 1 Protein Recombinant Fusion Proteins Transcription Factors promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein Myeloid-Lymphoid Leukemia Protein Tretinoin Histone-Lysine N-Methyltransferase