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PMID: 10391241 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Hox genes in brachiopods and priapulids and protostome evolution.

Nature ·Vol. 399 ·No. 6738 ·1999-06-24 ·Pages 772-6

de Rosa R, Grenier JK, Andreeva T, Cook CE, Adoutte A, Akam M, Carroll SB, Balavoine G

Abstract

Understanding the early evolution of animal body plans requires knowledge both of metazoan phylogeny and of the genetic and developmental changes involved in the emergence of particular forms. Recent 18S ribosomal RNA phylogenies suggest a three-branched tree for the Bilateria comprising the deuterostomes and two great protostome clades, the lophotrochozoans and ecdysozoans. Here, we show that the complement of Hox genes in critical protostome phyla reflects these phylogenetic relationships and reveals the early evolution of developmental regulatory potential in bilaterians. We have identified Hox genes that are shared by subsets of protostome phyla. These include a diverged pair of posterior (Abdominal-B-like) genes in both a brachiopod and a polychaete annelid, which supports the lophotrochozoan assemblage, and a distinct posterior Hox gene shared by a priapulid, a nematode and the arthropods, which supports the ecdysozoan clade. The ancestors of each of these two major protostome lineages had a minimum of eight to ten Hox genes. The major period of Hox gene expansion and diversification thus occurred before the radiation of each of the three great bilaterian clades.

MeSH Terms

Amino Acid Sequence Animals Biological Evolution Genes, Homeobox Invertebrates/classification,genetics Molecular Sequence Data Phylogeny Sequence Alignment

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

de Rosa R

Laboratoire de Biologie Cellulaire 4, CNRS UPRESA Q8080, Université Paris-Sud, Orsay, France.

Grenier J K

Andreeva T

Cook C E

Adoutte A

Akam M

Carroll S B

Balavoine G

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/21631

Published

1999-06-24

Pages

772-6

Language

English

Region

England

NLM ID

0410462

Subset

Grants

Wellcome Trust · United Kingdom

Databases

GENBANK

AF144666, AF144667, AF144668, AF144669, AF144670, AF144671, AF144672, AF144673, AF144674, AF144675, AF144676, AF144677, AF144678, AF144679, AF144680, AF144884, AF144885, AF144886, AF144887, AF144888, AF144889, AF144890, AF144891, AF144892, AF144893, AF151663, AF151664, AF151665, AF151666, AF151667

Corrections

CommentIn

PMID: 10391234

External Links

PubMed source DOI: 10.1038/21631 View journal details

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Hox genes in brachiopods and priapulids and protostome evolution.

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