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PMID: 10388983 Published · ppublish English Clinical Trial Comparative Study Journal Article Multicenter Study Randomized Controlled Trial Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Increased small dense LDL and intermediate-density lipoprotein with albuminuria in type 1 diabetes.

Diabetes care ·Vol. 22 ·No. 7 ·1999-07-00 ·Pages 1165-70

Sibley SD, Hokanson JE, Steffes MW, Purnell JQ, Marcovina SM, Cleary PA, Brunzell JD

Abstract

This population study examines the relationship between LDL density and persistent albuminuria in subjects with type 1 diabetes at the end of the Diabetes Control and Complications Trial (DCCT). Subjects were classified as persistently normoalbuminuric (albumin excretion rate [AER] < 30 mg/d, n = 1,056), microalbuminuric (AER > or = 30-299 mg/day, n = 80), and macroalbuminuric (AER = 300 mg/day, n = 24) based on the last two AER measures. Triglyceride (P < 0.01) and LDL cholesterol (P < 0.01) levels were higher in macroalbuminuric subjects compared with normoalbuminuric subjects. Cholesterol distribution by density-gradient ultracentrifugation showed an increase in intermediate-density lipoprotein (IDL) and a shift in peak LDL from buoyant toward more dense particles with progressive albuminuria. In the entire group, there was a significant negative correlation between the peak buoyancy of LDL particles and albuminuria (r = -0.238, P < 0.001, n = 1,160). This correlation persisted in the normoalbuminuric DCCT group (r = -0.138, P < 0.001, n = 1,056). As albuminuria increases in subjects with type 1 diabetes, dyslipidemia occurs with an increase in IDL and dense LDL that may lead to increased cardiovascular disease.

MeSH Terms
Adolescent Adult Albuminuria/blood Body Mass Index Cholesterol, LDL/blood Diabetes Mellitus, Type 1/blood,physiopathology,urine Female Humans Lipoproteins/blood Lipoproteins, IDL Lipoproteins, LDL/blood Male Reference Values Regression Analysis Triglycerides/blood
Chemicals
Cholesterol, LDL Lipoproteins Lipoproteins, IDL Lipoproteins, LDL Triglycerides
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Sibley S D
Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle 98195, USA. ssibley@u.washington.edu
Hokanson J E
Steffes M W
Purnell J Q
Marcovina S M
Cleary P A
Brunzell J D
References (35)
35 references, click to expand
  1. Microalbuminuria and associated cardiovascular risk factors in the community.
    Atherosclerosis. 1992 Mar;93(1-2):71-81 PMID: 1596306
  2. Baseline analysis of renal function in the Diabetes Control and Complications Trial. The Diabetes Control and Complications Trial Research Group [corrected].
    Kidney Int. 1993 Mar;43(3):668-74 PMID: 8455366
  3. International Federation of Clinical Chemistry standardization project for measurements of apolipoproteins A-I and B. III. Comparability of apolipoprotein A-I values by use of international reference material.
    Clin Chem. 1993 May;39(5):773-81 PMID: 8485867
  4. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.
    N Engl J Med. 1993 Sep 30;329(14):977-86 PMID: 8366922
  5. Pattern of hyperlipoproteinemia in human nephrotic syndrome: influence of renal failure and diabetes mellitus.
    Nephron. 1993;64(4):565-9 PMID: 8366982
  6. International Federation of Clinical Chemistry standardization project for measurements of apolipoproteins A-I and B. IV. Comparability of apolipoprotein B values by use of International Reference Material.
    Clin Chem. 1994 Apr;40(4):586-92 PMID: 8149615
  7. LDL subclasses in IDDM patients: relation to diabetic nephropathy.
    Diabetologia. 1994 Jul;37(7):681-8 PMID: 7958539
  8. Effect of the number of apolipoprotein(a) kringle 4 domains on immunochemical measurements of lipoprotein(a).
    Clin Chem. 1995 Feb;41(2):246-55 PMID: 7533064
  9. Effect of intensive diabetes management on macrovascular events and risk factors in the Diabetes Control and Complications Trial.
    Am J Cardiol. 1995 May 1;75(14):894-903 PMID: 7732997
  10. Prognostic significance of microalbuminuria in insulin-dependent diabetes mellitus: a twenty-three year follow-up study.
    Kidney Int. 1992 Apr;41(4):836-9 PMID: 1513106
  11. Effect of hepatic lipase on LDL in normal men and those with coronary artery disease.
    Arterioscler Thromb. 1993 Feb;13(2):147-53 PMID: 8427851
  12. Influence of early diabetic nephropathy on very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL), and low density lipoprotein (LDL) composition.
    Atherosclerosis. 1991 Jul;89(1):49-57 PMID: 1772471
  13. Abnormalities of lipoprotein metabolism in patients with the nephrotic syndrome.
    N Engl J Med. 1990 Aug 30;323(9):579-84 PMID: 2381443
  14. Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk.
    Circulation. 1990 Aug;82(2):495-506 PMID: 2372896
  15. Alterations in serum lipids and apolipoproteins in male type 1 (insulin-dependent) diabetic patients with microalbuminuria.
    Diabetologia. 1989 Sep;32(9):685-9 PMID: 2507381
  16. Large buoyant LDL-like particles in hepatic lipase deficiency.
    Arteriosclerosis. 1989 May-Jun;9(3):319-25 PMID: 2719594
  17. Serum lipids and lipoproteins in insulin-dependent diabetic patients with persistent microalbuminuria.
    Diabet Med. 1989 Jan-Feb;6(1):25-30 PMID: 2522370
  18. Inheritance of low-density lipoprotein subclass patterns: results of complex segregation analysis.
    Am J Hum Genet. 1988 Dec;43(6):838-46 PMID: 3195585
  19. Proteinuria: value as predictor of cardiovascular mortality in insulin dependent diabetes mellitus.
    Br Med J (Clin Res Ed). 1987 Jun 27;294(6588):1651-4 PMID: 3113569
  20. Intermediate-density lipoproteins and progression of coronary artery disease in hypercholesterolaemic men.
    Lancet. 1987 Jul 11;2(8550):62-6 PMID: 2885572
  21. Increased atherogenicity of low-density lipoprotein in heavy proteinuria.
    Nephrol Dial Transplant. 1998 May;13(5):1183-8 PMID: 9623551
  22. Predictors of mortality in insulin dependent diabetes: 10 year observational follow up study.
    BMJ. 1996 Sep 28;313(7060):779-84 PMID: 8842069
  23. Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies.
    J Cardiovasc Risk. 1996 Apr;3(2):213-9 PMID: 8836866
  24. Compositional differences of LDL particles in normal subjects with LDL subclass phenotype A and LDL subclass phenotype B.
    Arterioscler Thromb Vasc Biol. 1996 Aug;16(8):1040-6 PMID: 8696944
  25. Multiple lipoprotein abnormalities in type I diabetic patients with renal disease.
    Diabetes. 1996 Jul;45(7):974-9 PMID: 8666151
  26. Levels of lipoprotein(a), apolipoprotein B, and lipoprotein cholesterol distribution in IDDM. Results from follow-up in the Diabetes Control and Complications Trial.
    Diabetes. 1995 Oct;44(10):1218-26 PMID: 7556961
  27. Effect of intensive therapy on the development and progression of diabetic nephropathy in the Diabetes Control and Complications Trial. The Diabetes Control and Complications (DCCT) Research Group.
    Kidney Int. 1995 Jun;47(6):1703-20 PMID: 7643540
  28. Proteinuria and mortality in diabetes: the WHO Multinational Study of Vascular Disease in Diabetes.
    Diabet Med. 1995 Feb;12(2):149-55 PMID: 7743762
  29. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study.
    Am J Med. 1977 May;62(5):707-14 PMID: 193398
  30. 1983 metropolitan height and weight tables.
    Stat Bull Metrop Life Found. 1983 Jan-Jun;64(1):3-9 PMID: 6623350
  31. Apoproteins B and A-I and coronary artery disease in humans.
    Arteriosclerosis. 1984 Mar-Apr;4(2):79-83 PMID: 6422918
  32. Lipid abnormalities in insulin-dependent diabetic patients with albuminuria.
    Diabetes Care. 1984 Mar-Apr;7(2):151-4 PMID: 6734382
  33. The effect of proteinuria on relative mortality in type 1 (insulin-dependent) diabetes mellitus.
    Diabetologia. 1985 Aug;28(8):590-6 PMID: 4054448
  34. The Diabetes Control and Complications Trial (DCCT). Design and methodologic considerations for the feasibility phase. The DCCT Research Group.
    Diabetes. 1986 May;35(5):530-45 PMID: 2869996
  35. Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus.
    Am J Cardiol. 1987 Apr 1;59(8):750-5 PMID: 3825934
Article Info
Journal
Diabetes care
Abbr.
Diabetes Care
ISSN
0149-5992
DOI
10.2337/diacare.22.7.1165
Email
ssibley@u.washington.edu
Published
1999-07-00
Pages
1165-70
Language
English
Region
United States
NLM ID
7805975
PMCID
PMC2635089
Subset
IM
Grants
NIDDK NIH HHS · N01 DK062204-007 · United States
NIDDK NIH HHS · P01 DK002456 · United States
NIDDK NIH HHS · DK-02456 · United States
Corrections
ErratumIn
-
External Links
PubMed source DOI: 10.2337/diacare.22.7.1165 PMC Full Text View journal details
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