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题目:: Rescue of cyclin D1 deficiency by knockin cyclin E.
作者:: Geng(Y),Whoriskey(W),Park(M Y),Bronson(R T),Medema(R H),Li(T),Weinberg(R A),Sicinski(P)
状态:: 发布时间1999-07-22 , 更新时间 2007-11-14
期刊:: Cell
摘要:: D-type cyclins and cyclin E represent two very distinct classes of mammalian G1 cyclins. We have generated a mouse strain in which the coding sequences of the cyclin D1 gene (Ccnd1) have been deleted and replaced by those of human cyclin E (CCNE). In the tissues and cells of these mice, the expression pattern of human cyclin E faithfully reproduces that normally associated with mouse cyclin D1. The replacement of cyclin D1 with cyclin E rescues all phenotypic manifestations of cyclin D1 deficiency and restores normal development in cyclin D1-dependent tissues. Thus, cyclin E can functionally replace cyclin D1. Our analyses suggest that cyclin E is the major downstream target of cyclin D1.
语言:: eng
DOI:

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