Abstract
The activity of antibodies against filoviruses is poorly understood but has important consequences for vaccine design and passive prophylaxis. To investigate this activity, a panel of recombinant human monoclonal antibodies to Ebola virus antigens was isolated from phage display libraries constructed from RNA from donors who recovered from infection in the 1995 Ebola virus outbreak in Kikwit, Democratic Republic of Congo. Antibodies reactive with nucleoprotein (NP), envelope glycoprotein (GP), and secreted envelope glycoprotein (sGP) were characterized by immunofluorescence and radioimmunoprecipitation assays. Four antibodies reacting strongly with sGP and weakly with GP and two antibodies reacting with NP were not neutralizing. An antibody specific for GP neutralized Ebola virus to 50% at 0.4 microgram/ml as the recombinant Fab fragment and to 50% at 0.3 microgram/ml (90% at 2.6 microgram/ml) as the corresponding whole immunoglobulin G1 molecule. The studies indicate that neutralizing antibodies are produced in infection by Ebola virus although probably at a relatively low frequency. The neutralizing antibody may be useful in vaccine design and as a prophylactic agent against Ebola virus infection.
MeSH Terms
Amino Acid Sequence
Animals
Antibodies, Viral/immunology
Antibody Affinity
Antigens, Viral/immunology
Chlorocebus aethiops
Democratic Republic of the Congo/epidemiology
Disease Outbreaks
Ebolavirus/immunology
Fluorescent Antibody Technique, Direct
Gene Library
Glycoproteins/immunology
Hemorrhagic Fever, Ebola/blood,epidemiology,immunology
Humans
Immunoglobulin Fab Fragments/immunology,isolation & purification
Molecular Sequence Data
Neutralization Tests
Nucleocapsid Proteins/immunology
Radioimmunoprecipitation Assay
Vero Cells
Viral Envelope Proteins/immunology
Viral Proteins
Chemicals
Antibodies, Viral
Antigens, Viral
Glycoproteins
Immunoglobulin Fab Fragments
Nucleocapsid Proteins
Viral Envelope Proteins
Viral Proteins
envelope glycoprotein, Ebola virus
nucleocapsid protein, Ebola virus
secreted glycoprotein, Ebola virus
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Maruyama T
Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
Rodriguez L L
Jahrling P B
Sanchez A
Khan A S
Nichol S T
Peters C J
Parren P W
Burton D R
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