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PMID: 10355032 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

GATA transcription factors and cardiac development.

Seminars in cell & developmental biology ·Vol. 10 ·No. 1 ·1999-02-00 ·Pages 85-91

Charron F, Nemer M

Abstract

Three members of the GATA family of transcription factors, GATA-4, -5, and -6, are expressed in the developing heart. One family member, GATA-5, is restricted to the endocardium while the other two, GATA-4 and -6, are present in the myocardium where they apparently fulfil distinct functions. The mechanisms underlying GATA factor specificity are not fully understood but may involve interaction with other tissue-restricted or ubiquitous co-factors. Thus, combinatorial interaction among GATA factors or between GATA factors and other co-factors may differentially control various stages of cardiogenesis.

MeSH Terms

Animals Bone Morphogenetic Proteins/genetics,physiology Cardiomegaly/genetics Chickens DNA-Binding Proteins/genetics,physiology GATA4 Transcription Factor GATA5 Transcription Factor GATA6 Transcription Factor Gene Expression Regulation, Developmental Heart/embryology,growth & development Homeobox Protein Nkx-2.5 Homeodomain Proteins/genetics,physiology Humans Mice Myocardium/metabolism Rats Signal Transduction/genetics Transcription Factors/genetics,physiology Xenopus Xenopus Proteins

Chemicals

Bone Morphogenetic Proteins DNA-Binding Proteins GATA-5a protein, Xenopus GATA-5b protein, Xenopus GATA4 Transcription Factor GATA4 protein, Xenopus GATA5 Transcription Factor GATA5 protein, human GATA6 Transcription Factor GATA6 protein, Xenopus GATA6 protein, human Gata5 protein, mouse Gata5 protein, rat Gata6 protein, mouse Homeobox Protein Nkx-2.5 Homeodomain Proteins NKX2-5 protein, Xenopus NKX2-5 protein, human Nkx2-5 protein, mouse Transcription Factors Xenopus Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Charron F

Institut de recherches cliniques de Montréal, Laboratoire de développement et différenciation cardiaques, Québec, Canada.

Nemer M

Article Info

Journal

Seminars in cell & developmental biology

Abbr.

Semin Cell Dev Biol

ISSN

1084-9521

DOI

10.1006/scdb.1998.0281

Published

1999-02-00

Pages

85-91

Language

English

Region

England

NLM ID

9607332

Subset

External Links

PubMed source DOI: 10.1006/scdb.1998.0281 View journal details

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