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PMID: 10354593 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Pathoadaptive mutations: gene loss and variation in bacterial pathogens.

Trends in microbiology ·Vol. 7 ·No. 5 ·1999-05-00 ·Pages 191-5

Sokurenko EV, Hasty DL, Dykhuizen DE

Abstract

Pathogenicity-adaptive, or pathoadaptive, mutations represent a genetic mechanism for enhancing bacterial virulence without horizontal transfer of specific virulence factors. Pathoadaptive evolution can be important within single infections and for defining the population structure of a pathogenic species.

MeSH Terms
Adaptation, Physiological Bacterial Physiological Phenomena Evolution, Molecular Genes, Bacterial Genetic Variation Humans Mutation
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sokurenko E V
Dept of Microbiology, University of Washington, Seattle, WA 98195, USA.evs@u.washington.edu
Hasty D L
Dykhuizen D E
Article Info
Journal
Trends in microbiology
Abbr.
Trends Microbiol
ISSN
0966-842X
DOI
10.1016/s0966-842x(99)01493-6
Email
usa.evs@u.washington.edu
Published
1999-05-00
Pages
191-5
Language
English
Region
England
NLM ID
9310916
Subset
IM
External Links
PubMed source DOI: 10.1016/s0966-842x(99)01493-6 View journal details
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