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PMID: 10318895 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Exon repetition in mRNA.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 96 ·No. 10 ·1999-05-11 ·Pages 5400-5

Frantz SA, Thiara AS, Lodwick D, Ng LL, Eperon IC, Samani NJ

Abstract

The production of different transcripts (transcript heterogeneity) is a feature of many genes that may result in phenotypic variation. Several mechanisms, that occur at both the DNA and RNA level have been shown to contribute to this transcript heterogeneity in mammals, all of which involve either the rearrangement of sequences within a genome or the use of alternative signals in linear, contiguous DNA or RNA. Here we describe tissue-specific repetition of selective exons in transcripts of a rat gene (SA) with a normal exon-intron organization. We conclude that nonlinear mRNA processing can generate tissue-specific transcripts.

MeSH Terms
Animals Cells, Cultured Coenzyme A Ligases Exons/genetics Kidney Tubules, Proximal/metabolism Liver/metabolism Polymerase Chain Reaction Proteins/genetics RNA Processing, Post-Transcriptional/genetics RNA, Messenger/genetics Rats Rats, Inbred SHR Rats, Inbred WKY Repetitive Sequences, Nucleic Acid/genetics Restriction Mapping Ribonuclease H/metabolism
Chemicals
Proteins RNA, Messenger Ribonuclease H Acsm3 protein, rat Coenzyme A Ligases
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Frantz S A
Department of Cardiology, University of Leicester, Leicester LE3 9QP, United Kingdom.
Thiara A S
Lodwick D
Ng L L
Eperon I C
Samani N J
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.96.10.5400
Published
1999-05-11
Pages
5400-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC21871
Subset
IM
Grants
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1073/pnas.96.10.5400 PMC Full Text View journal details
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