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PMID: 10209157 Published · ppublish English Comparative Study Journal Article Review

Multiple signals converging on NF-kappaB.

Current opinion in cell biology ·Vol. 11 ·No. 2 ·1999-04-00 ·Pages 226-32

Mercurio F, Manning AM

Abstract

The recent identification of molecular components of the signal transduction pathway regulating activation of nuclear factor-kappaB (NF-kappaB) in response to cytokines such as tumor necrosis factor alpha and interleukin-1beta allows the evaluation of how other diverse stimuli impinge on the NF-kappaB activation pathway. These studies suggest a basis for specificity in activation of specific Rel-related family members and the genetic responses they promote.

MeSH Terms
Amino Acid Sequence Animals Calcium-Calmodulin-Dependent Protein Kinases/physiology DNA-Binding Proteins/physiology Embryonic and Fetal Development Extremities/embryology Gene Expression Regulation/physiology I-kappa B Proteins Inflammation/physiopathology Mice Mice, Mutant Strains Models, Biological Molecular Sequence Data Morphogenesis NF-kappa B/physiology Osteoclasts/cytology Protein Kinases/physiology Sequence Alignment Sequence Homology, Amino Acid Signal Transduction/physiology Stress, Physiological/physiopathology Transcription, Genetic/physiology
Chemicals
DNA-Binding Proteins I-kappa B Proteins NF-kappa B Protein Kinases Calcium-Calmodulin-Dependent Protein Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Mercurio F
Signal Pharmaceuticals Inc, 5555 Oberlin Drive, San Diego, CA 92121, USA. fmercuri@signalpharm.com
Manning A M
Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
0955-0674
DOI
10.1016/s0955-0674(99)80030-1
Email
fmercuri@signalpharm.com
Published
1999-04-00
Pages
226-32
Language
English
Region
England
NLM ID
8913428
Subset
IM
External Links
PubMed source DOI: 10.1016/s0955-0674(99)80030-1 View journal details
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