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PMID: 10203523 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Second generation of the automated Cobas Amplicor HCV assay improves sensitivity of hepatitis C virus RNA detection and yields results that are more clinically relevant.

Journal of clinical microbiology ·Vol. 37 ·No. 5 ·1999-05-00 ·Pages 1567-9

Doglio A, Laffont C, Caroli-Bosc FX, Rochet P, Lefebvre J

Abstract

The first and second generations of the Cobas Amplicor HCV assay were compared among patients at risk of hepatitis C virus (HCV) infection. The second-generation test was found to be of greater sensitivity and of good specificity among clinical specimens containing HCV RNA of different genotypes. Finally, this new test is shown to predict the outcome of interferon therapy better.

MeSH Terms

Hepacivirus/genetics Hepatitis C/therapy Humans Interferons/therapeutic use RNA, Viral/analysis Sensitivity and Specificity

Chemicals

RNA, Viral Interferons

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Doglio A

Laboratoire de Virologie, Faculté de Médecine, 06107 Nice, France. doglio@unice.fr

Laffont C

Caroli-Bosc F X

Rochet P

Lefebvre J

References (11)

11 references, click to expand

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Article Info

Journal

Journal of clinical microbiology

Abbr.

J Clin Microbiol

ISSN

0095-1137

DOI

10.1128/JCM.37.5.1567-1569.1999

doglio@unice.fr

Published

1999-05-00

Pages

1567-9

Language

English

Region

United States

NLM ID

7505564

PMCID

PMC84830

Subset

External Links

PubMed source DOI: 10.1128/JCM.37.5.1567-1569.1999 PMC Full Text View journal details

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Second generation of the automated Cobas Amplicor HCV assay improves sensitivity of hepatitis C virus RNA detection and yields results that are more clinically relevant.

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