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PMID: 10196590 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Plasticity of temporal information processing in the primary auditory cortex.

Nature neuroscience ·Vol. 1 ·No. 8 ·1998-12-00 ·Pages 727-31

Kilgard MP, Merzenich MM

Abstract

Neurons in the rat primary auditory cortex (A1) generally cannot respond to tone sequences faster than 12 pulses per second (pps). To test whether experience can modify this maximum following rate in adult rats, trains of brief tones with random carrier frequency but fixed repetition rate were paired with electrical stimulation of the nucleus basalis (NB) 300 to 400 times per day for 20-25 days. Pairing NB stimulation with 5-pps stimuli markedly decreased the cortical response to rapidly presented stimuli, whereas pairing with 15-pps stimuli significantly increased the maximum cortical following rate. In contrast, pairing with fixed carrier frequency 15-pps trains did not significantly increase the mean maximum following rate. Thus this protocol elicits extensive cortical remodeling of temporal response properties and demonstrates that simple differences in spectral and temporal features of the sensory input can drive very different cortical reorganizations.

MeSH Terms
Acoustic Stimulation/methods Animals Auditory Cortex/physiology Electric Stimulation/methods Female Neuronal Plasticity/physiology Rats Substantia Innominata/physiology Time Perception/physiology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kilgard M P
Coleman Laboratory, Department of Otolaryngology, University of California at San Francisco 94143-0444, USA. kilgard@phy.ucsf.edu
Merzenich M M
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Article Info
Journal
Nature neuroscience
Abbr.
Nat Neurosci
ISSN
1097-6256
DOI
10.1038/3729
Email
kilgard@phy.ucsf.edu
Published
1998-12-00
Pages
727-31
Language
English
Region
United States
NLM ID
9809671
PMCID
PMC2948964
Subset
IM
Grants
NINDS NIH HHS · F32 NS010414 · United States
NINDS NIH HHS · R01 NS010414 · United States
NINDS NIH HHS · R01 NS010414-27 · United States
NINDS NIH HHS · NS-10414 · United States
External Links
PubMed source DOI: 10.1038/3729 PMC Full Text View journal details
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