beta-lactamase stability of HR 756, a novel cephalosporin, compared to that of cefuroxime and cefoxitin.
The stability to beta-lactamase hydrolysis of HR 756, a new cephalosporin antibiotic, was compared to the beta-lactamase stability of cefoxitin and cefuroxime. HR 756, cefoxitin, and cefuroxime were not hydrolyzed by Richmond type I, III, IV, and V beta-lactamases. Antibacterial activity of HR 756 correlated well with resistance to beta-lactamase hydrolysis except against Pseudomonas aeruginosa. HR 756, cefoxitin, and cefuroxime inhibited type I beta-lactamases, but not type III, IV, or V enzymes. HR 756 was the most active inhibitor.
13 references, click to expand
-
Potent combinations of beta-lactam antibiotics using the beta-lactamase inhibition principle.Chemotherapy. 1975;21(6):330-41 PMID: 1102266
-
Cefoxitin, a semisynthetic cephamycin antibiotic: antibacterial spectrum and resistance to hydrolysis by gram-negative beta-lactamases.Antimicrob Agents Chemother. 1974 Aug;6(2):170-6 PMID: 15828188
-
Experimental evaluation of HR756, a new cephalosporin derivative: pre-clinical study.Infection. 1977;5(4):259-60 PMID: 413795
-
Inhibition of the -lactamases of Escherichia coli and Klebsiella aerogenes by semi-synthetic penicillins.Biochem J. 1972 Mar;127(1):295-308 PMID: 4561388
-
The beta-lactamases of gram-negative bacteria and their possible physiological role.Adv Microb Physiol. 1973;9:31-88 PMID: 4581138
-
Inhibition of beta-lactamases by beta-lactam antibiotics.Antimicrob Agents Chemother. 1972 Dec;2(6):442-8 PMID: 4670438
-
In vitro synergistic effect of netilmicin, a new aminoglycoside antibiotic.Antimicrob Agents Chemother. 1976 Sep;10(3):511-8 PMID: 791104
-
Formation of beta-lactamase in Bacteroides fragilis: cell-bound and extracellular activity.Antimicrob Agents Chemother. 1976 May;9(5):727-35 PMID: 7997
-
Cefoxitin resistance to beta-lactamase: a major factor for susceptibility of bacteroides fragilis to the antibiotic.Antimicrob Agents Chemother. 1977 Apr;11(4):725-34 PMID: 856025
-
Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus.Antimicrob Agents Chemother. 1977 May;11(5):852-7 PMID: 879738
-
Cefuroxime - a new cephalosporin antibiotic.J Antibiot (Tokyo). 1976 Jan;29(1):29-37 PMID: 931792
-
Naturally-occurring beta-lactamase inhibitors with antibacterial activity.J Antibiot (Tokyo). 1976 Jun;29(6):668-9 PMID: 950324
-
Substrate inhibition of beta-lactamases, a method for predicting enzymatic stability of cephalosporins.Antimicrob Agents Chemother. 1976 Sep;10(3):470-5 PMID: 984790
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
