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PMID: 10097140 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 96 ·No. 7 ·1999-03-30 ·Pages 3928-33

Ishii H, Baffa R, Numata SI, Murakumo Y, Rattan S, Inoue H, Mori M, Fidanza V, Alder H, Croce CM

Abstract

Alterations of human chromosome 8p occur frequently in many tumors. We identified a 1.5-Mb common region of allelic loss on 8p22 by allelotype analysis. cDNA selection allowed isolation of several genes, including FEZ1. The predicted Fez1 protein contained a leucine-zipper region with similarity to the DNA-binding domain of the cAMP-responsive activating-transcription factor 5. RNA blot analysis revealed that FEZ1 gene expression was undetectable in more than 60% of epithelial tumors. Mutations were found in primary esophageal cancers and in a prostate cancer cell line. Transcript analysis from several FEZ1-expressing tumors revealed truncated mRNAs, including a frameshift. Alteration and inactivation of the FEZ1 gene may play a role in various human tumors.

MeSH Terms
Adaptor Proteins, Signal Transducing Amino Acid Sequence Breast Neoplasms/genetics Chromosome Mapping Chromosomes, Human, Pair 8 Cloning, Molecular DNA-Binding Proteins/biosynthesis,chemistry,genetics Esophageal Neoplasms/genetics Female Gene Library Genes, Tumor Suppressor Humans Leucine Zippers Loss of Heterozygosity Male Molecular Sequence Data Neoplasms/genetics Nerve Tissue Proteins Ovarian Neoplasms/genetics Prostatic Neoplasms/genetics RNA, Messenger/analysis Reverse Transcriptase Polymerase Chain Reaction Sequence Alignment Sequence Homology, Amino Acid Testis/metabolism Transcription, Genetic Tumor Cells, Cultured Tumor Suppressor Proteins
Chemicals
Adaptor Proteins, Signal Transducing DNA-Binding Proteins FEZ1 protein, human LZTS1 protein, human Nerve Tissue Proteins RNA, Messenger Tumor Suppressor Proteins
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Ishii H
Kimmel Cancer Institute, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Baffa R
Numata S I
Murakumo Y
Rattan S
Inoue H
Mori M
Fidanza V
Alder H
Croce C M
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.96.7.3928
Published
1999-03-30
Pages
3928-33
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC22397
Subset
IM
Grants
NCI NIH HHS · CA39860 · United States
NCI NIH HHS · CA51083 · United States
NCI NIH HHS · CA56336 · United States
Databases
GENBANK
AF123652, AF123653, AF123654, AF123655, AF123656, AF123657, AF123658, AF123659
External Links
PubMed source DOI: 10.1073/pnas.96.7.3928 PMC Full Text View journal details
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