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PMID: 10097038 Published · ppublish English Comment Journal Article Review

Microbial polyketide synthases: more and more prolific.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 96 ·No. 7 ·1999-03-30 ·Pages 3336-8

Hutchinson CR

Abstract

暂无摘要

MeSH Terms
Bacteria/enzymology Cloning, Molecular/methods Genetic Engineering Multienzyme Complexes/biosynthesis Recombinant Proteins/biosynthesis Saccharopolyspora/enzymology Streptomyces/enzymology
Chemicals
Multienzyme Complexes Recombinant Proteins
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hutchinson C R
References (27)
27 references, click to expand
  1. Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.
    Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):1846-51 PMID: 10051557
  2. Combinatorial biosynthesis for new drug discovery.
    Curr Opin Microbiol. 1998 Jun;1(3):319-29 PMID: 10066498
  3. Ectopic expression of the minimal whiE polyketide synthase generates a library of aromatic polyketides of diverse sizes and shapes.
    Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3622-7 PMID: 10097087
  4. Genetic Contributions to Understanding Polyketide Synthases.
    Chem Rev. 1997 Nov 10;97(7):2465-2498 PMID: 11851466
  5. Biosynthetic Studies of Daunorubicin and Tetracenomycin C.
    Chem Rev. 1997 Nov 10;97(7):2525-2536 PMID: 11851469
  6. Manipulation of Modular Polyketide Synthases.
    Chem Rev. 1997 Nov 10;97(7):2557-2576 PMID: 11851471
  7. Harnessing the Biosynthetic Potential of Modular Polyketide Synthases.
    Chem Rev. 1997 Nov 10;97(7):2577-2590 PMID: 11851472
  8. Biosynthesis of Erythromycin and Rapamycin.
    Chem Rev. 1997 Nov 10;97(7):2611-2630 PMID: 11851474
  9. Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin.
    J Biol Chem. 1992 Sep 25;267(27):19278-90 PMID: 1527048
  10. Modular organization of genes required for complex polyketide biosynthesis.
    Science. 1991 May 3;252(5006):675-9 PMID: 2024119
  11. An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea.
    Nature. 1990 Nov 8;348(6297):176-8 PMID: 2234082
  12. Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tü22.
    EMBO J. 1989 Sep;8(9):2717-25 PMID: 2583128
  13. Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.
    EMBO J. 1989 Sep;8(9):2727-36 PMID: 2684656
  14. Chemical Biology of Epothilones.
    Angew Chem Int Ed Engl. 1998 Aug 17;37(15):2014-2045 PMID: 29711063
  15. The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin.
    Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7839-43 PMID: 7644502
  16. Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits.
    Nature. 1995 Jun 15;375(6532):549-54 PMID: 7791871
  17. Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase.
    Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11542-6 PMID: 7972098
  18. Correlation of the avermectin polyketide synthase genes to the avermectin structure. Implications for designing novel avermectins.
    Ann N Y Acad Sci. 1994 May 2;721:123-32 PMID: 8010663
  19. Engineered biosynthesis of a complete macrolactone in a heterologous host.
    Science. 1994 Jul 22;265(5171):509-12 PMID: 8036492
  20. An erythromycin analog produced by reprogramming of polyketide synthesis.
    Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7119-23 PMID: 8346223
  21. Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase.
    Science. 1997 Jul 18;277(5324):367-9 PMID: 9219693
  22. Engineered intermodular and intramodular polyketide synthase fusions.
    Chem Biol. 1997 Sep;4(9):667-74 PMID: 9331407
  23. Engineering broader specificity into an antibiotic-producing polyketide synthase.
    Science. 1998 Jan 9;279(5348):199-202 PMID: 9422686
  24. Applications of DNA shuffling to pharmaceuticals and vaccines.
    Curr Opin Biotechnol. 1997 Dec;8(6):724-33 PMID: 9425664
  25. Purification and in vitro reconstitution of the essential protein components of an aromatic polyketide synthase.
    Biochemistry. 1998 Feb 24;37(8):2084-8 PMID: 9518007
  26. Reconstitution of the iterative type II polyketide synthase for tetracenomycin F2 biosynthesis.
    Biochemistry. 1998 Jun 2;37(22):8132-8 PMID: 9609708
  27. Harnessing the biosynthetic code: combinations, permutations, and mutations.
    Science. 1998 Oct 2;282(5386):63-8 PMID: 9756477
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.96.7.3336
Published
1999-03-30
Pages
3336-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC34269
Subset
IM
Corrections
CommentOn
PMID: 10051557
CommentOn
PMID: 10097087
External Links
PubMed source DOI: 10.1073/pnas.96.7.3336 PMC Full Text View journal details
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