Home LiteratureArticle Details

PMID: 10091993 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) encodes a homologue of the Epstein-Barr virus bZip protein EB1.

The Journal of general virology ·Vol. 80 ( Pt 3) ·1999-03-00 ·Pages 557-561

Gruffat H, Portes-Sentis S, Sergeant A, Manet E

Abstract

Analysis of the recently completed genomic sequence of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) revealed that ORF 50 encodes a protein with homology to the Epstein-Barr virus (EBV) transcription factor R. In this report, we show that ORF K8, contiguous to ORF 50, is interrupted by two introns and that the spliced RNA is translated into a bZip protein that has homology to the EBV transcription factor EB1. The newly characterized K8 protein forms homodimers but does not heterodimerize with other members of the bZip protein family.

MeSH Terms

Amino Acid Sequence Basic-Leucine Zipper Transcription Factors Carrier Proteins/chemistry,genetics,metabolism Cell Line DNA Primers DNA-Binding Proteins/biosynthesis,chemistry,genetics Dimerization Herpesvirus 4, Human/genetics Herpesvirus 8, Human/genetics,growth & development Humans Introns/genetics Leucine Zippers Molecular Sequence Data Open Reading Frames/genetics Precipitin Tests Protein Binding Protein Biosynthesis RNA Splicing/genetics RNA, Messenger/genetics,metabolism Recombinant Fusion Proteins/biosynthesis,chemistry,genetics,metabolism Repressor Proteins Reverse Transcriptase Polymerase Chain Reaction Sequence Deletion Sequence Homology, Amino Acid Trans-Activators/biosynthesis,chemistry,genetics Viral Proteins/biosynthesis,chemistry,genetics,metabolism

Chemicals

BZLF1 protein, Herpesvirus 4, Human Basic-Leucine Zipper Transcription Factors Carrier Proteins DNA Primers DNA-Binding Proteins K8 protein, Human herpesvirus 8 RNA, Messenger Recombinant Fusion Proteins Repressor Proteins Trans-Activators Viral Proteins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Gruffat H

Portes-Sentis S

Sergeant A

Manet E

Article Info

Journal

The Journal of general virology

Abbr.

J Gen Virol

ISSN

0022-1317

DOI

10.1099/0022-1317-80-3-557

Published

1999-03-00

Pages

557-561

Language

English

Region

England

NLM ID

0077340

Subset

Databases

GENBANK

AJ011499

External Links

PubMed source DOI: 10.1099/0022-1317-80-3-557 View journal details

Analysis Services

Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) encodes a homologue of the Epstein-Barr virus bZip protein EB1.

Contact

WeChat Official Account