Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT.

Amino Acid Sequence Animals Calcineurin/physiology Calcineurin Inhibitors Calcium/physiology Calcium Signaling Cardiomegaly/genetics,physiopathology,prevention & control Cyclosporine/pharmacology,therapeutic use DNA-Binding Proteins/physiology Dose-Response Relationship, Drug Gene Expression Regulation Humans Immunosuppressive Agents/pharmacology,therapeutic use Mice Models, Biological Molecular Sequence Data Multigene Family Myocardium/metabolism NFATC Transcription Factors Nuclear Proteins Organ Specificity Protein Isoforms/physiology Sequence Alignment Sequence Homology, Amino Acid Signal Transduction/physiology Tacrolimus/pharmacology,therapeutic use Transcription Factors/physiology Transfection

Calcineurin Inhibitors DNA-Binding Proteins Immunosuppressive Agents NFATC Transcription Factors NFATC1 protein, human NFATC3 protein, human NFATC4 protein, human Nuclear Proteins Protein Isoforms Transcription Factors Cyclosporine Calcineurin Calcium Tacrolimus