Home LiteratureArticle Details
PMID: 1008841 Published · ppublish English Journal Article

Collagen synthesis and deposition in cartilage during disrupted proteoglycan production.

The Biochemical journal ·Vol. 160 ·No. 1 ·1976-10-15 ·Pages 117-20

Dondi P, Muir H

Abstract

A simple system was developed to investigate in vitro the possible relationship between collagen and proteoglycan synthesis in cartilage. When production of complete proteoglycan molecules was effectively inhibited with 4-methylumbelliferyl beta-D-xyloside collagen synthesis and distribution were virtually unaffected.

MeSH Terms
Animals Cartilage/drug effects,metabolism Collagen/biosynthesis Glycosaminoglycans/analysis Glycosides/pharmacology Hymecromone/analogs & derivatives,pharmacology In Vitro Techniques Proteoglycans/biosynthesis Swine Umbelliferones/pharmacology
Chemicals
Glycosaminoglycans Glycosides Proteoglycans Umbelliferones Hymecromone Collagen
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dondi P
Muir H
References (10)
10 references, click to expand
  1. A modified uronic acid carbazole reaction.
    Anal Biochem. 1962 Oct;4:330-4 PMID: 13971270
  2. Hyaluronic acid in cartilage and proteoglycan aggregation.
    Biochem J. 1974 Jun;139(3):565-81 PMID: 4277512
  3. Stimulation of synthesis of free chondroitin sulfate chains by beta-D-xylosides in cultured cells.
    Proc Natl Acad Sci U S A. 1974 Oct;71(10):4047-51 PMID: 4372604
  4. The molecular-weight distribution of glycosaminoglycans.
    Biochem J. 1973 Dec;135(4):631-7 PMID: 4273184
  5. Biosynthesis of proteoglycans in cartilage slices. Fractionation by gel chromatography and equilibrium density-gradient centrifugation.
    Biochem J. 1972 Feb;126(4):791-803 PMID: 4262896
  6. Dissociation of the synthesis of sulphated mucopolysaccharides and the synthesis of collagen in embryonic cartilage.
    Biochim Biophys Acta. 1966 Dec 28;130(2):383-92 PMID: 4226472
  7. Stimulation of synthesis of free chondroitin sulfate chains by beta-D-xylosides in cultured cells.
    J Biol Chem. 1975 Jul 25;250(14):5400-6 PMID: 167013
  8. Stimulation of chondroitin sulfate proteoglycan production by chondrocytes in monolayer.
    Connect Tissue Res. 1975;3(2):115-22 PMID: 126838
  9. Effect of beta-D-xylosides on collagen synthesis in cultured fibroblasts.
    Biochem Biophys Res Commun. 1975 Dec 1;67(3):1108-13 PMID: 1201062
  10. The effect of D-xylose, beta-D-xylosides and beta-D-galactosides on chondroitin sulphate biosynthesis in embryonic chicken cartilage.
    Biochem J. 1975 Apr;148(1):25-34 PMID: 1156397
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1600117
Published
1976-10-15
Pages
117-20
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1164207
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1600117 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2