Home LiteratureArticle Details

PMID: 10074554 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Allelic diversity of the Helicobacter pylori vacuolating cytotoxin gene in South Africa: rarity of the vacA s1a genotype and natural occurrence of an s2/m1 allele.

Journal of clinical microbiology ·Vol. 37 ·No. 4 ·1999-04-00 ·Pages 1203-5

Letley DP, Lastovica A, Louw JA, Hawkey CJ, Atherton JC

Abstract

We describe the rarity of Helicobacter pylori strains of vacuolating cytotoxin type s1a (the type most commonly associated with peptic ulceration in the United States) among black and mixed-race South Africans. We also provide the first description of a naturally occurring strain with the vacA allelic structure s2/m1.

MeSH Terms

Alleles Antigens, Bacterial Bacterial Proteins/genetics Gastritis/epidemiology,microbiology Genes, Bacterial Genetic Variation Genotype Helicobacter Infections/epidemiology,microbiology Helicobacter pylori/genetics,isolation & purification Humans Peptic Ulcer/epidemiology,microbiology South Africa/epidemiology

Chemicals

Antigens, Bacterial Bacterial Proteins VacA protein, Helicobacter pylori cagA protein, Helicobacter pylori

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Letley D P

Division of Gastroenterology, University of Nottingham, Nottingham, United Kingdom.

Lastovica A

Louw J A

Hawkey C J

Atherton J C

References (12)

12 references, click to expand

Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains.
J Biol Chem. 1994 Apr 8;269(14):10566-73 PMID: 8144644
Panmictic structure of Helicobacter pylori demonstrated by the comparative study of six genetic markers.
FEMS Microbiol Lett. 1998 Apr 15;161(2):231-9 PMID: 9570115
Helicobacter pylori: the African enigma.
Gut. 1992 Apr;33(4):429-31 PMID: 1582581
Fast and sensitive multiple sequence alignments on a microcomputer.
Comput Appl Biosci. 1989 Apr;5(2):151-3 PMID: 2720464
Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease.
J Exp Med. 1994 May 1;179(5):1653-58 PMID: 8163943
Population genetic analysis of Helicobacter pylori by multilocus enzyme electrophoresis: extensive allelic diversity and recombinational population structure.
J Bacteriol. 1996 Jul;178(13):3934-8 PMID: 8682800
Molecular Methods for Detecting Ulcerogenic Strains of H. pylori.
Methods Mol Med. 1997;8:133-43 PMID: 21351029
Genetic relationship among isolates of Helicobacter pylori: evidence for the existence of a Helicobacter pylori species-complex.
FEMS Microbiol Lett. 1997 May 1;150(1):27-32 PMID: 9163902
Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori.
Gastroenterology. 1997 Jan;112(1):92-9 PMID: 8978347
Cytotoxic activity in broth-culture filtrates of Campylobacter pylori.
J Med Microbiol. 1988 Jun;26(2):93-9 PMID: 3385767
cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors.
Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14648-53 PMID: 8962108
Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration.
J Biol Chem. 1995 Jul 28;270(30):17771-7 PMID: 7629077

Article Info

Journal

Journal of clinical microbiology

Abbr.

J Clin Microbiol

ISSN

0095-1137

DOI

10.1128/JCM.37.4.1203-1205.1999

Published

1999-04-00

Pages

1203-5

Language

English

Region

United States

NLM ID

7505564

PMCID

PMC88677

Subset

External Links

PubMed source DOI: 10.1128/JCM.37.4.1203-1205.1999 PMC Full Text View journal details

Analysis Services

Allelic diversity of the Helicobacter pylori vacuolating cytotoxin gene in South Africa: rarity of the vacA s1a genotype and natural occurrence of an s2/m1 allele.

Contact

WeChat Official Account