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PMID: 10074445 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Actin polymerization: Where the WASP stings.

Current biology : CB ·Vol. 9 ·No. 5 ·1999-03-11 ·Pages R160-3

Bi E, Zigmond SH

Abstract

How do extracellular signals induce actin polymerization, as required for many cellular responses? Key signal transducers, such as the small GTPases Cdc42 and Rac, have now been shown to link via proteins of the WASP family to the Arp2/3 complex, which nucleates actin polymerization.

MeSH Terms

Actin-Related Protein 2 Actin-Related Protein 3 Actins/metabolism Amino Acid Sequence Animals Cytoskeletal Proteins Humans Molecular Sequence Data Polymers Proteins/metabolism Signal Transduction Wiskott-Aldrich Syndrome Wiskott-Aldrich Syndrome Protein

Chemicals

ACTR2 protein, human ACTR3 protein, human Actin-Related Protein 2 Actin-Related Protein 3 Actins Cytoskeletal Proteins Polymers Proteins WAS protein, human Wiskott-Aldrich Syndrome Protein

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Bi E

Departments of Cell and Developmental Biology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6018, USA.

Zigmond S H

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(99)80102-x

Published

1999-03-11

Pages

R160-3

Language

English

Region

England

NLM ID

9107782

Subset

Grants

NIAID NIH HHS · AI 19883 · United States

External Links

PubMed source DOI: 10.1016/s0960-9822(99)80102-x View journal details

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Actin polymerization: Where the WASP stings.

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