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PMID: 10072355 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Ras caught in another affair: the exchange factors for Ral.

Current opinion in genetics & development ·Vol. 9 ·No. 1 ·1999-02-00 ·Pages 112-7

Wolthuis RM, Bos JL

Abstract

The Ral guanine nucleotide exchange factors are direct targets of Ras, providing a mechanism for Ral activation by extracellular signals. In addition, Ral can be activated by a Ras-independent pathway. Ral guanine nucleotide exchange factors contribute to cellular transformation induced by oncogenic Ras through an Erk-independent mechanism which may involve activation of transcription.

MeSH Terms

Enzyme Activation GTP Phosphohydrolases/metabolism GTP-Binding Proteins/metabolism Guanine Nucleotide Exchange Factors Guanosine Triphosphate/metabolism Humans Proteins/metabolism ral GTP-Binding Proteins rap GTP-Binding Proteins ras Guanine Nucleotide Exchange Factors ras Proteins/physiology

Chemicals

Guanine Nucleotide Exchange Factors Proteins ras Guanine Nucleotide Exchange Factors Guanosine Triphosphate GTP Phosphohydrolases GTP-Binding Proteins ral GTP-Binding Proteins rap GTP-Binding Proteins ras Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Wolthuis R M

Laboratory for Physiological Chemistry, Center for Biomedical Genetics,Stratenum, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands.

Bos J L

Article Info

Journal

Current opinion in genetics & development

Abbr.

Curr Opin Genet Dev

ISSN

0959-437X

DOI

10.1016/s0959-437x(99)80016-1

Published

1999-02-00

Pages

112-7

Language

English

Region

England

NLM ID

9111375

Subset

External Links

PubMed source DOI: 10.1016/s0959-437x(99)80016-1 View journal details

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Ras caught in another affair: the exchange factors for Ral.

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