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PMID: 10021452 Published · ppublish English Case Reports Journal Article Research Support, U.S. Gov't, P.H.S.

Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection.

The Journal of clinical investigation ·Vol. 103 ·No. 4 ·1999-02-00 ·Pages 453-60

Haynes BF, Hale LP, Weinhold KJ, Patel DD, Liao HX, Bressler PB, Jones DM, Demarest JF, Gebhard-Mitchell K, Haase AT, Bartlett JA

Abstract

A key question in understanding the status of the immune system in HIV-1 infection is whether the adult thymus contributes to reconstitution of peripheral T lymphocytes. We analyzed the thymus in adult patients who died of HIV-1 infection. In addition, we studied the clinical course of HIV-1 infection in three patients thymectomized for myasthenia gravis and determined the effect of antiretroviral therapy on CD4(+) T cells. We found that five of seven patients had thymus tissue at autopsy and that all thymuses identified had inflammatory infiltrates surrounding lymphodepleted thymic epithelium. Two of seven patients also had areas of thymopoiesis; one of these patients had peripheral blood CD4(+) T-cell levels of <50/mm3 for 51 months prior to death. Of three thymectomized patients, one rapidly progressed to AIDS, one progressed to AIDS over seven years (normal progressor), whereas the third remains asymptomatic at least seven years after seroconversion. Both latter patients had rises in peripheral blood CD4(+) T cells after antiretroviral therapy. Most patients who died of complications of HIV-1 infection did not have functional thymus tissue, and when present, thymopoiesis did not prevent prolonged lymphopenia. Thymectomy before HIV-1 infection did not preclude either peripheral CD4(+) T-cell rises or clinical responses after antiretroviral therapy.

MeSH Terms
Adolescent Adult CD4-Positive T-Lymphocytes/cytology,immunology Female HIV Infections/complications,immunology,pathology,virology HIV-1/genetics,immunology Humans Male Middle Aged Thymectomy Thymus Gland/cytology,immunology,pathology
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Haynes B F
Department of Medicine, Duke Center for AIDS Research, Duke University Medical Center, Durham, North Carolina 27710, USA. Hayne002@mc.duke.edu
Hale L P
Weinhold K J
Patel D D
Liao H X
Bressler P B
Jones D M
Demarest J F
Gebhard-Mitchell K
Haase A T
Bartlett J A
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
Published
1999-02-00
Pages
453-60
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC408098
Subset
IM
Grants
NIAID NIH HHS · R37 AI028246 · United States
NIAID NIH HHS · AI-28246 · United States
NIAID NIH HHS · AI-28662 · United States
NCI NIH HHS · CA-28936 · United States
Corrections
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