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PMID: 10021355 Published · ppublish English Journal Article Review

Cancer genetics: tumor suppressor meets oncogene.

Current biology : CB ·Vol. 9 ·No. 2 ·1999-01-28 ·Pages R62-5

Fearon ER, Dang CV

Abstract

The adenomatous polyposis coli (APC) tumor suppressor protein is inactivated by mutations in the majority of colorectal cancers. A recent study has revealed that alterations in the APC signaling pathway can result in the transcriptional activation of the c-MYC gene.

MeSH Terms
Genes, APC Genes, myc Humans Mutation Oncogenes Signal Transduction Transcriptional Activation
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Fearon E R
Division of Molecular Medicine and Genetics, Department of Internal Medicine, Human Genetics, University of Michigan Cancer Center, Ann Arbor, 48109-0638 USA. fearon@umich.edu
Dang C V
Article Info
Journal
Current biology : CB
Abbr.
Curr Biol
ISSN
0960-9822
DOI
10.1016/s0960-9822(99)80012-8
Email
fearon@umich.edu
Published
1999-01-28
Pages
R62-5
Language
English
Region
England
NLM ID
9107782
Subset
IM
External Links
PubMed source DOI: 10.1016/s0960-9822(99)80012-8 View journal details
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