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PMID: 10021341 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping.

Development (Cambridge, England) ·Vol. 126 ·No. 6 ·1999-03-00 ·Pages 1225-34

Campione M, Steinbeisser H, Schweickert A, Deissler K, van Bebber F, Lowe LA, Nowotschin S, Viebahn C, Haffter P, Kuehn MR, Blum M

Abstract

Left-right asymmetry in vertebrates is controlled by activities emanating from the left lateral plate. How these signals get transmitted to the forming organs is not known. A candidate mediator in mouse, frog and zebrafish embryos is the homeobox gene Pitx2. It is asymmetrically expressed in the left lateral plate mesoderm, tubular heart and early gut tube. Localized Pitx2 expression continues when these organs undergo asymmetric looping morphogenesis. Ectopic expression of Xnr1 in the right lateral plate induces Pitx2 transcription in Xenopus. Misexpression of Pitx2 affects situs and morphology of organs. These experiments suggest a role for Pitx2 in promoting looping of the linear heart and gut.

MeSH Terms

Abnormalities, Multiple/embryology Activins Amino Acid Sequence Animals Body Patterning Cell Communication Digestive System/embryology Gastrula Gene Expression Regulation, Developmental Genes, Homeobox Heart/embryology Homeodomain Proteins/metabolism Inhibins/metabolism Intracellular Signaling Peptides and Proteins Mice Mice, Mutant Strains Molecular Sequence Data Morphogenesis Nodal Protein Nuclear Proteins Paired Box Transcription Factors Sequence Homology, Amino Acid Species Specificity Tissue Distribution Transcription Factors/metabolism Transforming Growth Factor beta/biosynthesis,metabolism Vertebrates/embryology Xenopus Xenopus Proteins Zebrafish Zebrafish Proteins

Chemicals

Homeodomain Proteins Intracellular Signaling Peptides and Proteins Nodal Protein Nodal protein, mouse Nuclear Proteins Paired Box Transcription Factors Transcription Factors Transforming Growth Factor beta Xenopus Proteins Zebrafish Proteins homeobox protein PITX1 homeobox protein PITX3 ndr2 protein, zebrafish nodal1 protein, Xenopus Activins homeobox protein PITX2 Inhibins

Authors & Affiliations

11 authors, click to expand affiliations / ORCID

Campione M

Forschungszentrum Karlsruhe, Institute of Genetics, PO Box 3640, D-76021 Karlsruhe, Germany.

Steinbeisser H

Schweickert A

Deissler K

van Bebber F

Lowe L A

Nowotschin S

Viebahn C

Haffter P

Kuehn M R

Blum M

Article Info

Journal

Development (Cambridge, England)

Abbr.

Development

ISSN

0950-1991

Published

1999-03-00

Pages

1225-34

Language

English

Region

England

NLM ID

8701744

Subset

Databases

GENBANK

AJ005786, AJ005787

External Links

PubMed source View journal details

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The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping.

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