Lack of relationship between serum free fatty acids and impaired plasma protein binding of diphenylhydantoin in chronic renal failure.

European journal of clinical pharmacology ·Vol. 10 ·No. 6 ·1976-00-00 ·Pages 403-5

Odar-Cederlöf I, Borgå O

Abstract

The plasma protein binding of diphenyldantoin (DPH) in 13 patients with varying degrees of renal failure was considerably less than in normal healthy subjects confirming early studies. The fraction of unbound DPH was correlated with serum creatinine (r = 0.81, p less than 0.001), but there was no significant correlation with the serum concentration of free fatty acids, triglycerides or cholesterol.

MeSH Terms

Adult Aged Blood Proteins/metabolism Cholesterol/blood Creatinine/blood Fatty Acids, Nonesterified/blood Female Humans Kidney Failure, Chronic/blood Male Middle Aged Phenytoin/blood Protein Binding Triglycerides/blood

Chemicals

Blood Proteins Fatty Acids, Nonesterified Triglycerides Phenytoin Cholesterol Creatinine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Odar-Cederlöf I

Borgå O

References (19)

19 references, click to expand

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Article Info

Journal

European journal of clinical pharmacology

Abbr.

Eur J Clin Pharmacol

ISSN

0031-6970

DOI

10.1007/BF00563076

Published

1976-00-00

Pages

403-5

Language

English

Region

Germany

NLM ID

1256165

Subset

External Links

PubMed source DOI: 10.1007/BF00563076 View journal details

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Lack of relationship between serum free fatty acids and impaired plasma protein binding of diphenylhydantoin in chronic renal failure.

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