TOXICOLOGY AND APPLIED PHARMACOLOGY

简称 TOXICOL APPL PHARM ·UNITED STATES ·出版周期 Semimonthly ·年均收录 283 篇

3.4

最新影响因子

3.70%

自引率

50%

投稿难度

平均1.0个月来源Elsevier官…

审稿周期

期刊简介

TOXICOLOGY AND APPLIED PHARMACOLOGY是一本国际学术期刊，ISSN号为0041-008X，由美国学术出版社Elsevier出版，出版地为荷兰阿姆斯特丹，出版周期为半月刊。该期刊的影响因子根据年份不同有所波动，近年来保持在3.5至4.0左右，属于SCI收录期刊，中科院分区通常位于医学或毒理学领域的二区或三区。该期刊为非开放获取（非OA）期刊。其发文特点集中于毒理学和应用药理学领域，涵盖药物毒性、环境毒理、分子毒理、临床毒理及相关机制研究，尤其关注化学物质对生物体的毒性效应及其应用药理学解决方案。杂志以高质量的基础与临床研究为主，审稿严格，但近年来因竞争激烈，投稿难度有所增加，可能存在审稿周期较长或拒稿率较高的风险。总体而言，该期刊在毒理学领域具有较高学术声誉，是相关研究者发表前沿成果的重要平台。

影响因子趋势

近期发表

Inhibition of Calpain-1 ameliorates doxorubicin-induced cardiotoxicity by suppression of p53-mediated ferroptosis 2026-08-17

Physiologically based pharmacokinetic modeling of propofol: Impact of liver cirrhosis on systemic exposure and model-informed dose optimization according to Child–Pugh classification 2026-08-25

Mitochondrial complex I and II inhibiting pesticides activate DELE1-HRI integrated stress signaling but engage distinct cell death programs in human neuronal cells 2026-08-13

ΔA146Ply exerts anti-triple-negative breast cancer effects by inducing ferroptosis via regulation of the CYP24A1-mediated calcitriol-vitamin D receptor pathway 2026-08-30

Mitochondrial sensitivity to Ca2+-induced permeability transition in mouse liver exhibits time-of-day dependence 2026-08-19

Identification of candidate microRNA biomarkers of mouse cholangiocyte injury by global miRNAome analysis 2026-08-16

Irisin restores testicular metabolic homeostasis and spermatogenesis against chronic unpredictable stress in rats: An integrated 1H NMR metabolomics and molecular study 2026-08-26

Polystyrene nanoplastics exposure induces reproductive toxicity in male mice associated with the gut–liver/testis axis 2026-08-27

Anti-colorectal cancer activity of sertraline in mice involves regulation of arachidonic acid metabolism revealed by UPLC-Q Exactive Orbitrap MS-based metabolomics 2026-08-29

RAB17 downregulation elicits antitumor impacts in prostate cancer by triggering ferroptotic cell death through the regulation of TfR1-mediated iron overload 2026-08-27