WBP1（WW domain-binding protein 1）是一种与WW结构域相互作用的蛋白质，属于WBP家族成员之一。该基因编码的蛋白含有多个PPXY（脯氨酸-脯氨酸-任意氨基酸-酪氨酸）基序，可与含有WW结构域的蛋白（如泛素连接酶Nedd4家族）结合，参与蛋白质泛素化、信号转导和细胞周期调控等过程。WBP1在多种组织中表达，尤其在脑、心脏和骨骼肌中丰度较高。其生物学功能包括调控细胞增殖、分化和凋亡，并通过泛素-蛋白酶体系统影响靶蛋白的稳定性。WBP1的作用位点主要在细胞质和细胞核，通过与WW结构域蛋白的互作参与多种信号通路（如Notch、TGF-β通路）。突变可能导致其结合能力丧失，影响下游信号传导，例如某些癌症中WBP1异常表达与肿瘤进展相关。过表达WBP1可能增强泛素化依赖的蛋白降解，导致细胞周期紊乱或促凋亡效应；而低表达可能削弱相关通路调控，与神经退行性疾病或心血管异常有关。WBP家族（包括WBP1、WBP2等）的共同特征是含有PPXY基序，作为衔接蛋白介导WW结构域蛋白与底物的相互作用。目前研究发现WBP1与乳腺癌、胶质瘤等疾病存在关联，其过表达可能通过激活ErbB2/Her2通路促进肿瘤侵袭，而敲低表达则可能抑制癌细胞迁移。专业术语解释：WW结构域（由两个保守色氨酸W组成的蛋白相互作用模块）、泛素化（Ubiquitination，给靶蛋白添加泛素标记以调控其降解或功能）、PPXY基序（介导蛋白-蛋白相互作用的短氨基酸序列）。英文注释：WW domain（WW结构域）、ubiquitin ligase（泛素连接酶）、motif（基序）。

球状WW结构域，命名为在存在于各种结构和调节蛋白的蛋白质基序的保守的色氨酸残基，已知在蛋白质 - 蛋白质相互作用的调解作用。这个基因编码的是激酶相关蛋白的WW结构域的配体。邻近的上游基因，其编码INO80复合B亚基，这个基因的通读转录产生的非编码转录本。 [由RefSeq的，2011年2月提供]

WBP1, or WW domain-binding protein 1, is a multifunctional adaptor protein belonging to the WBP family, characterized by the presence of multiple PPXY (proline-proline-any amino acid-tyrosine) motifs that serve as critical docking sites for proteins containing WW domains, such as members of the Nedd4 family of E3 ubiquitin ligases. By mediating these specific protein-protein interactions, WBP1 acts as a central hub in cellular signaling, facilitating the ubiquitination of target proteins and thereby regulating their stability through the ubiquitin-proteasome system. This mechanism allows WBP1 to modulate diverse biological processes, including cell proliferation, differentiation, apoptosis, and cell cycle progression, with its functional activity localized primarily in both the cytoplasm and the nucleus. The protein is widely expressed across various tissues, exhibiting particularly high abundance in the brain, heart, and skeletal muscle, and it plays a pivotal role in transducing signals within key pathways such as Notch and TGF-β. In the context of disease, WBP1 has emerged as a significant player in oncology and neurodegeneration; for instance, its overexpression in breast cancer and glioma can promote tumor invasion and metastasis by enhancing the activation of the ErbB2/Her2 pathway and disrupting cell cycle checkpoints, whereas its knockdown inhibits cancer cell migration. Conversely, dysregulated WBP1 expression, including loss-of-function mutations that impair its binding capacity, has been linked to compromised signaling integrity, potentially contributing to cardiovascular abnormalities and neurodegenerative conditions, highlighting its dual role as a regulator of both homeostasis and pathological progression.

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