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题目:: Chromatin immunoprecipitation analysis of human hepatocyte regulatory circuitry
ID:
状态:: 发布时间May 9, 2006 , 更新时间 June 4, 2014 , 提交时间 May 9, 2006,
物种:: Homo sapiens
摘要:: We mapped the transcriptional regulatory circuitry for six master regulators in human hepatocytes using chromatin immunoprecipitation and high-resolution promoter microarrays. The results show that these regulators form a highly interconnected core circuitry, and reveal the local regulatory network motifs created by regulator-gene interactions. Auto-regulation was a prominent theme among these regulators. We found that hepatocyte master regulators tend to bind promoter regions combinatorially and that the number of transcription factors bound to a promoter corresponds with observed gene expression. Our studies reveal portions of the core circuitry of human hepatocytes.
实验种类:: ChIP-chip by array
样本量:: 1
实验设计:
: 无设计数据
数据号:: E-WMIT-9
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