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题目:: Comparative genomic hybridization by array of human intracranial childhood ependymomas at diagnosis and relapse
ID:
状态:: 发布时间Sept. 28, 2010 , 更新时间 May 2, 2014 , 提交时间 June 20, 2010,
物种:: Homo sapiens
摘要:: Goal of the experiment : Recurrence is a frequent phenomenon in intracranial childhood ependymomas. To understand this process, we investigated whether the gene expression profiling of matched ependymomas at diagnosis and at relapse could reveal key molecular events involved in tumor progression. To gain new insight in this process and identify mechanisms associated with recurrence, we compared the CGH profiles of local recurrences with the corresponding initial tumors. Brief description We analyzed 17 tumor samples at diagnosis and a total of 27 paired recurrences. Recurrences analyzed occurred after surgery only in 12 cases, surgery plus chemotherapy only in 9 cases and any treatment plus radiotherapy in 6 cases. We compared the level of CGH profile for each tumor at diagnosis and recurrence relative to normal commercial DNA using Agilent 4x44K Human CGH microarrays.
实验种类:: comparative genomic hybridization by array
样本量:: 46
实验设计:
: 无设计数据
数据号:: E-TABM-1023
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