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题目:: Transcription profiling of yeast expressing mouse major histocompatibility complex class I heavy chain H-2K(b)
ID:
状态:: 发布时间June 28, 2005 , 更新时间 March 27, 2012 , 提交时间 June 28, 2005,
物种:: Saccharomyces cerevisiae
摘要:: To dissect the requirements of membrane protein degradation from the ER, we expressed the mouse major histocompatibility complex class I heavy chain H-2K(b) in yeast. Like other proteins degraded from the ER, unassembled H-2K(b) heavy chains are not transported to the Golgi but are degraded in a proteasome-dependent manner. The overexpression of H-2K(b) heavy chains induces the unfolded protein response (UPR). In yeast mutants unable to mount the UPR, H-2K(b) heavy chains are greatly stabilized. This defect in degradation is suppressed by the expression of the active form of Hac1p, the transcription factor that upregulates UPR-induced genes. These results indicate that induction of the UPR is required for the degradation of protein substrates from the ER.
实验种类:: transcription profiling by array
样本量:: 0
实验设计:
: 无设计数据
数据号:: E-SMDB-1576
数据状态:: 无法自动分析，您可以尝试手动分析数据。

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