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E-MTAB-7744 RNA-seq of coding RNA from single cells Homo sapiens

Single cell experiment with iPS derived neural stem cells and 28 day differentiated neuronal cells from healthy individual and NRXN1-a biallelic deletion individual

提交 2015年11月4日 ·发布 2019年7月20日 ·更新 2019年7月19日

984

样本数

984

实验数

相关文献

实验描述

iPS cell derived neural stem cells and differentiated cells from one healthy individual and one indivudal carrying NRXN1-a biallelic deletion investigated with single cell RNA-sequencing. Celltype characterization and comparison revealed variations between stem cell identity and in cell differentiation outcome across the two individuals.

参考文献

Single cell analysis of autism patient with bi-allelic NRXN1-alpha deletion reveals skewed fate choice in neural progenitors and impaired neuronal functionality

Matti Lam, Mohsen Moslem, Julien Bryois, Robin J Pronk, Elias Uhlin, Ivar Dehnisch Ellström, Loora Laan, Jessica Olive, Rebecca Morse, Harriet Rönnholm, Lauri Louhivuori, Sergiy V Korol, Niklas Dahl, Per Uhlén, Britt-Marie Anderlid, Malin Kele, Patrick F Sullivan, Anna Falk

样本属性

age

undisclosed

cell type

differentiated cell from human iPS derived neural stem cell, human iPS derived neural stem cell

developmental stage

differentiated cell, neural stem cell

diff

.NES, DIFF

disease

autism spectrum disorder, healthy control, normal

folder_name

1772-099-229-Diff_NRXI-II-615, 1772-099-231-Diff_NRXI-II-616, 1772-099-233-Diff_NRXI-II-617, 1772-099-234-Diff_NRXI-II-613, 1772-099-253-Ctrl17_P12_DIFF_28-594, 1772-099-289-Ctrl7_II_P12_NES-595, 1772-099-290-Ctrl7_II_P12_NES-596, 1772-099-291-Ctrl7_II_P12_NES-597, 1772-099-292-Ctrl7_II_P12_NES-598, 1772-116-053-NRXI-III_P12-564, 1772-116-069-NRXI-III_P12-565, 1772-116-071-NRXI-III_P12-566, 1772-116-072-NRXI-III_P12-567, 1772-116-077-Ctrl17_P12_DIFF_28-591, 1772-116-078-Ctrl17_P12_DIFF_28-592, 1772-116-079-Ctrl17_P12_DIFF_28-593

individual

Ctrl-7, NRXN1-a del

organism

Homo sapiens

organism part

Cell

plate c1

1772-099-229, 1772-099-231, 1772-099-233, 1772-099-234, 1772-099-253, 1772-099-289, 1772-099-290, 1772-099-291, 1772-099-292, 1772-116-053, 1772-116-069, 1772-116-071, 1772-116-072, 1772-116-077, 1772-116-078, 1772-116-079

post analysis well quality

sample/well

A01, A02, A03, A04, A05, A06, A07, A08, A09, A10, A11, A12, B01, B02, B03, B04, B05, B06, B07, B08, B09, B10, B11, B12, C01, C02, C03, C04, C05, C06, C07, C08, C09, C10, C11, C12, D01, D02, D03, D04, D05, D06, D07, D08, D09, D10, D11, D12, E01, E02, E03, E04, E05, E06, E07, E08, E09, E10, E11, E12, F01, F02, F03, F04, F05, F06, F07, F08, F09, F10, F11, F12, G01, G02, G03, G04, G05, G06, G07, G08, G09, G10, G11, G12, H01, H02, H03, H04, H05, H06, H07, H08, H09, H10, H11, H12

sex

female, male

single cell well quality

实验信息

登记号

E-MTAB-7744

实验类型

RNA-seq of coding RNA from single cells

物种

Homo sapiens

提交日期

2015年11月4日

发布日期

2019年7月20日

更新日期

2019年7月19日

提交者

Matti Lam、 Anna Falk

外部链接

ArrayExpress 原始页

分析服务

Single cell experiment with iPS derived neural stem cells and 28 day differentiated neuronal cells from healthy individual and NRXN1-a biallelic deletion individual

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